(Q45862303)

17 December 2017

title

Stage-specific roles for CXCR4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation (English)

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17 December 2017

author

Masanori Nojima

10

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17 December 2017

Makoto Otsu

11

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17 December 2017

Shigeru Kakuta

Shigeru Kakuta

8

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Yoichiro Iwakura

Yoichiro Iwakura

9

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Hiromitsu Nakauchi

12

Hiromitsu Nakauchi

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17 December 2017

Masafumi Onodera

7

Masafumi Onodera

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17 December 2017

author name string

Chen-Yi Lai

1

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17 December 2017

Satoshi Yamazaki

2

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17 December 2017

Motohito Okabe

3

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17 December 2017

Sachie Suzuki

4

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17 December 2017

Yoshihiro Maeyama

5

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17 December 2017

Yasuaki Iimura

6

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17 December 2017

publication date

1 July 2014

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17 December 2017

published in

Stem Cells

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17 December 2017

volume

32

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17 December 2017

issue

7

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17 December 2017

page(s)

1929-1942

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17 December 2017

Transplantation of hematopoietic stem cells in human severe combined immunodeficiency: longterm outcomes

cites work

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Hematopoietic stem-cell transplantation

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Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer

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The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization

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Dormant and self-renewing hematopoietic stem cells and their niches

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Control of hematopoietic stem cells by the bone marrow stromal niche: the role of reticular cells

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CXCR4 is required for the quiescence of primitive hematopoietic cells

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Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

21 January 2018

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Hematopoietic stem cells are uniquely selective in their migratory response to chemokines

21 January 2018

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A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution

21 January 2018

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Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression

21 January 2018

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CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells

21 January 2018

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Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation

21 January 2018

1 reference

Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease

21 January 2018

1 reference

WHIM syndrome: a defect in CXCR4 signaling

21 January 2018

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AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome

21 January 2018

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WHIM syndrome myelokathexis reproduced in the NOD/SCID mouse xenotransplant model engrafted with healthy human stem cells transduced with C-terminus-truncated CXCR4

21 January 2018

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CXCR4 dimerization and beta-arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome.

21 January 2018

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Constitutive MAP kinase activation in hematopoietic stem cells induces a myeloproliferative disorder

21 January 2018

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Inducible gene targeting in mice

21 January 2018

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Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method

21 January 2018

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Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells

21 January 2018

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A new red fluorescent protein that allows efficient marking of murine hematopoietic stem cells

21 January 2018

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Adult mouse hematopoietic stem cells: purification and single-cell assays.

21 January 2018

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Feasibility of ex vivo gene therapy for neurological disorders using the new retroviral vector GCDNsap packaged in the vesicular stomatitis virus G protein

21 January 2018

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Potent vaccine therapy with dendritic cells genetically modified by the gene-silencing-resistant retroviral vector GCDNsap.

21 January 2018

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Enhanced function with decreased internalization of carboxy-terminus truncated CXCR4 responsible for WHIM syndrome

21 January 2018

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Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.

21 January 2018

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Asymmetric division and lineage commitment at the level of hematopoietic stem cells: inference from differentiation in daughter cell and granddaughter cell pairs

21 January 2018

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The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.

21 January 2018

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Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

21 January 2018

1 reference

Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines.

21 January 2018

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Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation

21 January 2018

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Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor

21 January 2018

1 reference

CXCL12/CXCR4-axis dysfunctions: Markers of the rare immunodeficiency disorder WHIM syndrome.

21 January 2018

1 reference

The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization

21 January 2018

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Homeostatic chemokine receptors and organ-specific metastasis

21 January 2018

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In vitro self-renewal division of hematopoietic stem cells

21 January 2018

1 reference

Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells

21 January 2018

1 reference

Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice

21 January 2018

1 reference

WHIM syndrome: congenital immune deficiency disease

21 January 2018

1 reference

CXC chemokine receptor 4 expressed in T cells plays an important role in the development of collagen-induced arthritis

21 January 2018

1 reference

The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice

21 January 2018

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Stromal-derived factor-1/CXCR4 signaling: indispensable role in homing and engraftment of hematopoietic stem cells in bone marrow

21 January 2018

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Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice

21 January 2018

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Is normal hematopoiesis maintained solely by long-term multipotent stem cells?

21 January 2018

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Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo

21 January 2018

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Enhanced functional response to CXCL12/SDF-1 through retroviral overexpression of CXCR4 on M07e cells: implications for hematopoietic stem cell transplantation

21 January 2018

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How do stem cells find their way home?

21 January 2018

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Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.1670

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17 December 2017

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17 December 2017