(Q45865514)

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Can the increasing number of newly developed leucine-rich repeat kinase 2 inhibitors validate or invalidate a potential disease-modifying therapeutic approach for Parkinson's disease?

scientific article published on 30 May 2014

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

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Can the increasing number of newly developed leucine-rich repeat kinase 2 inhibitors validate or invalidate a potential disease-modifying therapeutic approach for Parkinson's disease? (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

Parkinson's disease

1 reference

based on heuristic

inferred from title

Jean-Marc Taymans

1

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

language of work or name

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publication date

30 May 2014

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

Expert Opinion on Therapeutic Patents

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

24

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

7

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

727-730

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

What genetics tells us about the causes and mechanisms of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Molecular pathogenesis of Parkinson disease: insights from genetic studies

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Genome-wide association study reveals genetic risk underlying Parkinson's disease

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Kinases as targets for Parkinson's disease: from genetics to therapy

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Leucine-rich repeat kinase 2 inhibitors: a review of recent patents (2011 - 2013).

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 - 2011).

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Axon degeneration in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.915945

21 January 2018

Identifiers

10.1517/13543776.2014.915945

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

release_y4pgylruu5d4xoh2zawnzjkmn4

1 reference

https://api.fatcat.wiki/v0/release/y4pgylruu5d4xoh2zawnzjkmn4

24 November 2022

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mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24875782

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