(Q45869559)

17 December 2017

title

Switching the fiber knob of oncolytic adenoviruses to avoid neutralizing antibodies in human cancer patients (English)

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17 December 2017

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Akseli Hemminki

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Akseli Hemminki

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Timo Joensuu

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Minna Oksanen

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Sophie Escutenaire

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Anna Kanerva

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Lotta Kangasniemi

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Sari Pesonen

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object named as

Sari Pesonen

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author name string

Mari Raki

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Merja Sarkioja

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Elina Haavisto

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publication date

1 May 2011

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17 December 2017

published in

Journal of Gene Medicine

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17 December 2017

volume

13

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issue

5

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page(s)

253-261

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Oncolytic viruses in cancer therapy

cites work

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Immune responses to gene therapy vectors: influence on vector function and effector mechanisms

21 January 2018

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Impact of human neutralizing antibodies on antitumor efficacy of an oncolytic adenovirus in a murine model

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Treatment of metastatic renal cancer with capsid-modified oncolytic adenoviruses

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Ad5/3-9HIF-Delta24-VEGFR-1-Ig, an infectivity enhanced, dual-targeted and antiangiogenic oncolytic adenovirus for kidney cancer treatment

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Using a tropism-modified adenoviral vector to circumvent inhibitory factors in ascites fluid

21 January 2018

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An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression

21 January 2018

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Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses

21 January 2018

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Hexon gene switch strategy for the generation of chimeric recombinant adenovirus

21 January 2018

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Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery

21 January 2018

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Neutralizing antibodies to adenovirus serotype 5 vaccine vectors are directed primarily against the adenovirus hexon protein

21 January 2018

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Use of chimeric adenoviral vectors to assess capsid neutralization determinants.

21 January 2018

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Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity

21 January 2018

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Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies

21 January 2018

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Antipeptide antisera define neutralizing epitopes on the adenovirus hexon

21 January 2018

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Structure-based identification of a major neutralizing site in an adenovirus hexon

21 January 2018

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Identification of adenovirus (ad) penton base neutralizing epitopes by use of sera from patients who had received conditionally replicative ad (addl1520) for treatment of liver tumors

21 January 2018

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Decreased immune reactivity towards a knobless, affibody-targeted adenovirus type 5 vector

21 January 2018

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Mapping of linear epitopes on fibre knob of human adenovirus serotype 5.

21 January 2018

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An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches

21 January 2018

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Infectivity-enhanced adenoviruses deliver efficacy in clinical samples and orthotopic models of disseminated gastric cancer

21 January 2018

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Noninvasive imaging for evaluation of the systemic delivery of capsid-modified adenoviruses in an orthotopic model of advanced lung cancer.

21 January 2018

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Oncolytic adenovirus coding for granulocyte macrophage colony-stimulating factor induces antitumoral immunity in cancer patients

21 January 2018

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Treatment of cancer patients with a serotype 5/3 chimeric oncolytic adenovirus expressing GMCSF.

21 January 2018

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Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells

21 January 2018

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Prolonged systemic circulation of chimeric oncolytic adenovirus Ad5/3-Cox2L-D24 in patients with metastatic and refractory solid tumors

21 January 2018

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A modified E2F-1 promoter improves the efficacy to toxicity ratio of oncolytic adenoviruses.

21 January 2018

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Oncolytic adenovirus ICOVIR-7 in patients with advanced and refractory solid tumors

21 January 2018

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A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo.

21 January 2018

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21 January 2018

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Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirus-adenovirus receptor-independent gene transfer efficiency

21 January 2018

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Cryo-EM visualization of an exposed RGD epitope on adenovirus that escapes antibody neutralization

21 January 2018

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Preclinical Characterization of the Antiglioma Activity of a Tropism-Enhanced Adenovirus Targeted to the Retinoblastoma Pathway

21 January 2018

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Enhanced therapeutic efficacy for ovarian cancer with a serotype 3 receptor-targeted oncolytic adenovirus

21 January 2018

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Phase II Trial of Intravenous CI-1042 in Patients With Metastatic Colorectal Cancer

21 January 2018

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Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.

21 January 2018

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Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?

21 January 2018

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Clinical trials with oncolytic adenovirus in China

21 January 2018

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Intravascular adenoviral agents in cancer patients: lessons from clinical trials

21 January 2018

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Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells

21 January 2018

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Human CD8+ cytotoxic T cell responses to adenovirus capsid proteins.

21 January 2018

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Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy

21 January 2018

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A smart move against cancer for vaccinia virus

21 January 2018

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In situ adenovirus vaccination engages T effector cells against cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JGM.1565

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17 December 2017

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17 December 2017