(Q45885319)

17 December 2017

title

C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells (English)

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17 December 2017

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8

Kelly M McMasters

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17 December 2017

Robert C G Martin

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object named as

Robert C G Martin

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17 December 2017

author name string

Mary Jane Elliott

1

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17 December 2017

Ariel Stilwell

2

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17 December 2017

Yan Bin Dong

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17 December 2017

Hai Liang Yang

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17 December 2017

Sandra L Wong

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17 December 2017

William R Wrightson

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17 December 2017

publication date

1 May 2002

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17 December 2017

published in

Cancer Gene Therapy

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17 December 2017

volume

9

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17 December 2017

issue

5

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17 December 2017

page(s)

453-463

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700458

exact match

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cites work

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis

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Adenovirus-mediated E2F-1 gene transfer efficiently induces apoptosis in melanoma cells

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Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo

21 January 2018

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E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

21 January 2018

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21 January 2018

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Regulation of E2F: a family of transcription factors involved in proliferation control

21 January 2018

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The retinoblastoma protein and cell cycle control

21 January 2018

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Inhibitors of mammalian G1 cyclin-dependent kinases

21 January 2018

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Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

21 January 2018

1 reference

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Differential regulation of E2F transactivation by cyclin/cdk2 complexes

21 January 2018

1 reference

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Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation

21 January 2018

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Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

21 January 2018

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D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

21 January 2018

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

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Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors

21 January 2018

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Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.

21 January 2018

1 reference

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Role for cyclin A-dependent kinase in DNA replication in human S phase cell extracts

21 January 2018

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Inhibition of cyclin-dependent kinases by p21

21 January 2018

1 reference

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Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway

21 January 2018

1 reference

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Induction of growth arrest and cell death by overexpression of the cyclin-Cdk inhibitor p21 in hamster BHK21 cells

21 January 2018

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Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein

21 January 2018

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Regulation of the cdk inhibitor p21 gene during cell cycle progression is under the control of the transcription factor E2F.

21 January 2018

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p21 Disrupts the interaction between cdk2 and the E2F-p130 complex

21 January 2018

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p14ARF links the tumour suppressors RB and p53.

21 January 2018

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Tumor surveillance via the ARF-p53 pathway.

21 January 2018

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Role for the p53 homologue p73 in E2F-1-induced apoptosis

21 January 2018

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Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

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E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways

21 January 2018

1 reference

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Genetic determinants of p53-induced apoptosis and growth arrest

21 January 2018

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Caspases: the executioners of apoptosis

21 January 2018

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Protease activation during apoptosis: death by a thousand cuts?

21 January 2018

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

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Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

21 January 2018

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Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

21 January 2018

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Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins

21 January 2018

1 reference

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PCNA: structure, functions and interactions

21 January 2018

1 reference

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Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700458

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700458

E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700458

7 January 2021

Control of E2F activity by p21Waf1/Cip1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700458

7 January 2021

p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700458

7 January 2021

Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700458

7 January 2021

Functional analysis of a p21WAF1,CIP1,SDI1 mutant (Arg94 --> Trp) identified in a human breast carcinoma. Evidence that the mutation impairs the ability of p21 to inhibit cyclin-dependent kinases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700458

7 January 2021

Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700458

7 January 2021

Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CGT.7700458

7 January 2021

Identifiers

DOI

10.1038/SJ.CGT.7700458

1 reference

17 December 2017

Dimensions Publication ID

0 references

1 reference

17 December 2017