(Q45896474)

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Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.

scientific article published in August 2013

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7 March 2020

Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions (English)

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7 March 2020

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7 March 2020

Hermann Altmeppen

3

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7 March 2020

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7 March 2020

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Johannes Prox

1

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7 March 2020

Christian Bernreuther

2

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7 March 2020

Jasper Grendel

4

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7 March 2020

Rudi D'Hooge

6

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7 March 2020

Stijn Stroobants

7

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7 March 2020

Detlef Balschun

9

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7 March 2020

Michael Willem

10

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7 March 2020

Sven Lammich

11

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7 March 2020

Dirk Isbrandt

12

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7 March 2020

Michaela Schweizer

13

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7 March 2020

Katrien Horré

14

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7 March 2020

Paul Saftig

16

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7 March 2020

Bart De Strooper

15

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7 March 2020

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publication date

1 August 2013

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7 March 2020

Journal of Neuroscience

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7 March 2020

33

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7 March 2020

32

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7 March 2020

12915-28, 12928a

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7 March 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear Notch1 signaling and the regulation of dendritic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated cleavage of a contact-mediated axon repellent

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A CamKIIalpha iCre BAC allows brain-specific gene inactivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nectin: an adhesion molecule involved in formation of synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Theta oscillations in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal network patterns of activity in the mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Learning and memory deficits in Notch mutant mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficits in motor coordination with aberrant cerebellar development in mice lacking testicular orphan nuclear receptor 4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Klusters, NeuroScope, NDManager: a free software suite for neurophysiological data processing and visualization

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Learning-related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated ADAM10-dependent ectodomain shedding of gamma-protocadherin C3 modulates cell-cell adhesion

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metalloprotease-induced ectodomain shedding of neural cell adhesion molecule (NCAM).

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-secretase activation--an approach to Alzheimer's disease therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell adhesion molecules: signalling functions at the synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Theta-gamma coupling increases during the learning of item-context associations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta from axons and dendrites reduces local spine number and plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordination of size and number of excitatory and inhibitory synapses results in a balanced structural plasticity along mature hippocampal CA1 dendrites during LTP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of the alpha-secretase ADAM10--risk or reason for hope?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent alpha-cleavage of nectin-1 is mediated by a disintegrin and metalloprotease 10 (ADAM10).

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic organizing complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic localization and activity of ADAM10 regulate excitatory synapses through N-cadherin cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurexins and neuroligins: synapses look out of the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EphB controls NMDA receptor function and synaptic targeting in a subunit-specific manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAGUKs, synaptic development, and synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of Aβ, sAPPα and sAPPβ : similarities and differences

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of NMDA receptors upregulates a disintegrin and metalloproteinase 10 via a Wnt/MAPK signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of gamma oscillations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein (APP) regulates synaptic structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ectodomain shedding and ADAMs in development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent proteolytic cleavage of neuroligin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of synaptic potentiation in hippocampus by patterned stimulation involves two events

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/23926248

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5910-12.2013

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23926248%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23926248%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23926248%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

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