(Q45931929)

17 December 2017

title

New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease. (English)

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17 December 2017

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Zhonghua Li

1

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17 December 2017

Tiehai Li

2

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17 December 2017

Shaoxing Dai

3

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17 December 2017

Xiaoli Xie

4

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17 December 2017

Xiaofeng Ma

5

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17 December 2017

Wei Zhao

6

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17 December 2017

Weimin Zhang

7

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17 December 2017

Jing Li

8

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17 December 2017

Peng George Wang

9

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17 December 2017

publication date

14 June 2013

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17 December 2017

published in

ChemBioChem

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17 December 2017

volume

14

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17 December 2017

issue

10

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17 December 2017

page(s)

1239-1247

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17 December 2017

The cell biology of lysosomal storage disorders

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The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

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Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin

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Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease

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Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

21 January 2018

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Chemical and biological approaches synergize to ameliorate protein-folding diseases.

21 January 2018

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Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases

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21 January 2018

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New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening

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Polyhydroxylated bicyclic isoureas and guanidines are potent glucocerebrosidase inhibitors and nanomolar enzyme activity enhancers in Gaucher cells.

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Identifiers

DOI

10.1002/CBIC.201300197

1 reference

17 December 2017

1 reference

17 December 2017