(Q45936652)

English

Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition.

scientific article published on 7 July 2009

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Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

Zalypsis (PM00104) is a potent inducer of gamma-H2AX foci and reveals the importance of the C ring of trabectedin for transcription-coupled repair inhibition. (English)

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

3

object named as

Yves Pommier

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

author name string

Josée Guirouilh-Barbat

1

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

Smitha Antony

2

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

publication date

7 July 2009

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

Molecular Cancer Therapeutics

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

8

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

7

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

2007-2014

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7282704/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioactive compounds from aquatic and terrestrial sources

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone H2A variants H2AX and H2AZ

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GammaH2AX and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and crystal structures of ecteinascidins: potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sequence-selective binding of amiloride to DNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity- and gene expression-based profiling of ecteinascidin Et 743 and phthalascidin Pt 650.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additional antitumor ecteinascidins from a Caribbean tunicate: crystal structures and activities in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired expression of NER gene network in sporadic solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between nucleotide excision and homologous recombination DNA repair pathways in the mechanism of action of antitumor trabectedin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERCC1 and clinical resistance to platinum-based therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata

1 reference

https://pubmed.ncbi.nlm.nih.gov/19584237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/1535-7163.MCT-09-0336

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

18 December 2017

http://europepmc.org/abstract/MED/19584237

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