(Q45939742)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

title

Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

main subject

phase I clinical trial

0 references

1 reference

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

David E Piccioni

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Linda Liau

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1

Timothy F Cloughesy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

10

Albert Lai

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

2

Joseph Landolfi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

30

Michael A Vogelbaum

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

27

Derek Ostertag

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Stephen H. Bloomfield

4

object named as

Stephen Bloomfield

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

5

Bob Carter

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

8

Steven N Kalkanis

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

9

Santosh Kesari

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

19

Oscar R Diago

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

20

Dawn Gammon

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

24

Noriyuki Kasahara

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

23

Douglas J Jolly

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

21

Harry E Gruber

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

18

Asha Das

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

16

Tobias Walbert

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Phioanh Leia Nghiemphu

14

object named as

Phioanh Leia Nghiemphu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

author name string

Daniel J Hogan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Clark C Chen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

J Bradley Elder

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Tom Mikkelsen

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Alice Chu

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Michelle Hanna

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

David McCarthy

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Leah Mitchell

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Joan M Robbins

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

Maria Rodriguez-Aguirre

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

language of work or name

English

0 references

publication date

1 June 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

3 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

issue

341

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

page(s)

341ra75

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

Treatment options for glioblastoma

3 April 2020

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Beyond oncolytic virotherapy: replication-competent retrovirus vectors for selective and stable transduction of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Tumor-selective gene expression in a hepatic metastasis model after locoregional delivery of a replication-competent retrovirus vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

5-Fluorouracil can cross brain-blood barrier and cause encephalopathy: should we expect the same from capecitabine? A case report on capecitabine-induced central neurotoxicity progressing to coma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

The somatic genomic landscape of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Molecular heterogeneity in glioblastoma: potential clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Molecular subtypes of glioblastoma are relevant to lower grade glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

MRI-localized biopsies reveal subtype-specific differences in molecular and cellular composition at the margins of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

A novel literature-based approach to identify genetic and molecular predictors of survival in glioblastoma multiforme: Analysis of 14,678 patients using systematic review and meta-analytical tools.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Use of replication-competent retroviral vectors in an immunocompetent intracranial glioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Prognostic impact of MGMT promoter methylation and MGMT and CD133 expression in colorectal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: a pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Is surgery at progression a prognostic marker for improved 6-month progression-free survival or overall survival for patients with recurrent glioblastoma?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Response criteria for phase II studies of supratentorial malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.AAD9784

Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27252174

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27252174

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bystander effect caused by cytosine deaminase gene and 5-fluorocytosine in vitro is substantially mediated by generated 5-fluorouracil

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27252174

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.AAD9784

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27252174%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference