(Q46054824)

19 December 2017

title

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis (English)

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19 December 2017

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1

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19 December 2017

David M. Reif

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19 December 2017

Kevin M Crofton

9

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19 December 2017

Richard S. Judson

13

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19 December 2017

Kerry Hamilton

object named as

Kerry Hamilton

10

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Imran Shah

object named as

Imran Shah

12

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David J. Dix

2

object named as

David J Dix

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19 December 2017

author name string

Keith A Houck

3

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19 December 2017

Robert J Kavlock

4

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19 December 2017

Thomas B Knudsen

5

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19 December 2017

Matthew T Martin

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19 December 2017

Katie B Paul

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19 December 2017

Ronald Hunter

11

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19 December 2017

publication date

28 September 2012

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19 December 2017

published in

Toxicological Sciences

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19 December 2017

volume

131

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19 December 2017

issue

1

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19 December 2017

page(s)

40-55

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19 December 2017

Interferon-alpha, -beta and -gamma induce CXCL9 and CXCL10 secretion by human thyrocytes: modulation by peroxisome proliferator-activated receptor-gamma agonists

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CXCL9 and CXCL11 chemokines modulation by peroxisome proliferator-activated receptor-alpha agonists secretion in Graves' and normal thyrocytes.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

The age distribution of cancer and a multi-stage theory of carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Gene ontology: tool for the unification of biology

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Mining connections between chemicals, proteins, and diseases extracted from Medline annotations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

A new, quantitative, approach to the study of the stages of chemical cartinogenesis in the mouse's skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Characterization of compound mechanisms and secondary activities by BioMAP analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Toxicology. Transforming environmental health protection

21 January 2018

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Thyroid disrupting chemicals: mechanisms and mixtures

21 January 2018

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Mode of action: neurotoxicity induced by thyroid hormone disruption during development--hearing loss resulting from exposure to PHAHs

21 January 2018

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Ethylene thiourea (ETU). A review of the genetic toxicity studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

The ToxCast program for prioritizing toxicity testing of environmental chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

The initiation-promotion-progression model of rat hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Expression of TPO and ThOXs in human thyrocytes is downregulated by IL-1alpha/IFN-gamma, an effect partially mediated by nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Drug-induced thyroid disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Toxicogenomic effects common to triazole antifungals and conserved between rats and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Compendium of chemical carcinogens by target organ: results of chronic bioassays in rats, mice, hamsters, dogs, and monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

A general probabilistic model of carcinogenesis: analysis of experimental urinary bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

The guanylate binding protein-1 GTPase controls the invasive and angiogenic capability of endothelial cells through inhibition of MMP-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Creation of human tumour cells with defined genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Risk assessment of thyroid follicular cell tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Genetic alterations in thyroid tumor progression: association with p53 gene mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Toxicity testing in the 21st century: implications for human health risk assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

PPARalpha agonist-induced rodent tumors: modes of action and human relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Environmental impact on vascular development predicted by high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Antioncogenes and human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Mutation and cancer: statistical study of retinoblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Predictive model of rat reproductive toxicity from ToxCast high throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Mutation and cancer: a model for human carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Role of NF-kappaB in thyroid cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

WikiPathways: pathway editing for the people

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

CCL2, survivin and autophagy: new links with implications in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

CXC chemokines: the regulatory link between inflammation and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

High expression of the urokinase plasminogen activator and its cognate receptor associates with advanced stages and reduced disease-free interval in papillary thyroid carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Effects of pesticides on human peripheral lymphocytes in vitro: induction of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

Increased biliary excretion of thyroxine by microsomal enzyme inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

ACToR — Aggregated Computational Toxicology Resource

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFS285

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFS285

1 reference

19 December 2017

1 reference

19 December 2017