(Q46071071)

19 December 2017

title

Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors (English)

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19 December 2017

author name string

Dong Yin

1

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19 December 2017

Dong Xie

2

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19 December 2017

Wolf-Karsten Hofmann

3

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19 December 2017

Carl W Miller

4

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19 December 2017

Keith L Black

5

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19 December 2017

H Phillip Koeffler

6

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19 December 2017

language of work or name

English

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publication date

1 November 2002

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19 December 2017

published in

Oncogene

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19 December 2017

volume

21

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19 December 2017

page(s)

8372-8378

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19 December 2017

issue

54

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19 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206031

exact match

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cites work

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Rates of p16 (MTS1) mutations in primary tumors with 9p loss

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Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

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Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

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PTEN mutations in gliomas and glioneuronal tumors.

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Frequency and parental origin of hypermethylated RB1 alleles in retinoblastoma

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

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7 January 2021

Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

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7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

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7 January 2021

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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Germline p16 mutations in familial melanoma

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Highly frequent homozygous deletion of the p16 gene in esophageal cancer cell lines

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A cell cycle regulator potentially involved in genesis of many tumor types

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Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus

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7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

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Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

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5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

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7 January 2021

p14ARF deletion and methylation in genetic pathways to glioblastomas.

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Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

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Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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Mutations associated with familial melanoma impair p16INK4 function.

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The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53.

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Infrequent methylation of CDKN2A(MTS1/p16) and rare mutation of both CDKN2A and CDKN2B(MTS2/p15) in primary astrocytic tumours

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7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

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7 January 2021

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7 January 2021

Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomas.

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7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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7 January 2021

Promoter hypermethylation and homozygous deletion of the p14ARF and p16INK4a genes in oligodendrogliomas.

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7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206031

1 reference

19 December 2017

PubMed ID

12447702

1 reference

19 December 2017