(Q46084783)

English

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass

scientific article published on 18 March 2009

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scholarly article

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass (English)

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

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Christopher J. Nolan

2

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

author name string

V Delghingaro-Augusto

1

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

D Gupta

3

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

T L Jetton

4

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

M G Latour

5

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

M Peshavaria

6

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

S R Murthy Madiraju

7

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

E Joly

8

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

M-L Peyot

9

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

M Prentki

10

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

J Leahy

11

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

publication date

18 March 2009

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

52

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19 December 2017

http://europepmc.org/abstract/MED/19294363

6

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19 December 2017

http://europepmc.org/abstract/MED/19294363

1122-1132

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

https://scigraph.springernature.com/pub.10.1007/s00125-009-1317-8

0 references

Accelerated loss of islet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1007%2FS00125-009-1317-8

21 January 2018

The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes.

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https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

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Fatty acid signaling in the beta-cell and insulin secretion

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https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

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A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Stearoyl-CoA desaturase-1 and the metabolic syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

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Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

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beta-cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycerolipid metabolism and signaling in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose metabolism during the starved-to-fed transition in obese patients with NIDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

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The islet beta-cell: fuel responsive and vulnerable

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagonlike peptide-1 (7-37).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Psammomys obesus, a model for environment-gene interactions in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

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beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement in insulin secretion in diabetes after diazoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compensatory Adaption to Partial Pancreatectomy in the Rat*

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet beta cell failure in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular mechanisms of insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19294363

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-009-1317-8

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19294363

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