(Q46096916)

19 December 2017

title

Molecular mechanisms of programmed cell death-1 dependent T cell suppression: relevance for immunotherapy (English)

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19 December 2017

1 reference

Hugo Arasanz

5

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Grazyna Kochan

object named as

Grazyna Kochan

6

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author name string

Miren Zuazo

1

1 reference

19 December 2017

Maria Gato-Cañas

2

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19 December 2017

Noelia Llorente

3

1 reference

19 December 2017

María Ibañez-Vea

4

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19 December 2017

David Escors

7

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19 December 2017

publication date

1 October 2017

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19 December 2017

Annals of Translational Medicine

published in

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19 December 2017

volume

5

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19 December 2017

issue

19

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19 December 2017

page(s)

385

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19 December 2017

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

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24 May 2018

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PD-1 Blockade Expands Intratumoral Memory T Cells

24 May 2018

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PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

24 May 2018

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Programmed death-1 controls T cell survival by regulating oxidative metabolism.

24 May 2018

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Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy

24 May 2018

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PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

24 May 2018

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PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2

24 May 2018

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Strength of PD-1 signaling differentially affects T-cell effector functions.

24 May 2018

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Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells

24 May 2018

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T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

24 May 2018

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T cell replicative senescence in human aging

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation

24 May 2018

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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

24 May 2018

1 reference

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Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

The blockade of immune checkpoints in cancer immunotherapy

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

PD-L1 co-stimulation, ligand-induced TCR down-modulation and anti-tumor immunotherapy.

24 May 2018

1 reference

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PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells

24 May 2018

1 reference

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K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling

24 May 2018

1 reference

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PD-1 signaling in primary T cells

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Inhibitory B7-family molecules in the tumour microenvironment

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

T-cell tolerance or function is determined by combinatorial costimulatory signals

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Vav-family proteins in T-cell signalling

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

24 May 2018

The B7 family revisited

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A.

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

T cell receptor signalling

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5653513

15 August 2018

Identifiers

DOI

10.21037/ATM.2017.06.11

1 reference

19 December 2017

PMC publication ID

5653513

1 reference

19 December 2017

PubMed publication ID

29114543

1 reference

19 December 2017