(Q30515733)

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Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

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scholarly article

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Europe PubMed Central

11 August 2017

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. (English)

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Europe PubMed Central

11 August 2017

1 reference

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Akiko Hashimoto-Tane

object named as

Akiko Hashimoto-Tane

4

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object named as

Takashi Saito

6

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5

object named as

Miyuki Azuma

1 reference

Europe PubMed Central

11 August 2017

author name string

Tadashi Yokosuka

1

1 reference

Europe PubMed Central

11 August 2017

Masako Takamatsu

2

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Europe PubMed Central

11 August 2017

Wakana Kobayashi-Imanishi

3

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Europe PubMed Central

11 August 2017

language of work or name

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publication date

28 May 2012

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Europe PubMed Central

11 August 2017

Journal of Experimental Medicine

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Europe PubMed Central

11 August 2017

209

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Europe PubMed Central

11 August 2017

1201-1217

1 reference

Europe PubMed Central

11 August 2017

6

1 reference

Europe PubMed Central

11 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3371732/fullTextXML

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The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo

1 reference

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1 reference

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1 reference

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The immunological synapse, TCR microclusters, and T cell activation

1 reference

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PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia

1 reference

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Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

1 reference

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PD-1 signaling in primary T cells

1 reference

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Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters

1 reference

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Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation

1 reference

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1 reference

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1 reference

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Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen

1 reference

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PD-1 and its ligands in tolerance and immunity

1 reference

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20 June 2018

Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability

1 reference

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20 June 2018

Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation

1 reference

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20 June 2018

Reversal of the TCR stop signal by CTLA-4

1 reference

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20 June 2018

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

1 reference

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

1 reference

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Immunological synapse and microclusters: the site for recognition and activation of T cells

1 reference

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Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains

1 reference

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Restoring function in exhausted CD8 T cells during chronic viral infection

1 reference

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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

1 reference

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

1 reference

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CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function

1 reference

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T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

1 reference

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PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

1 reference

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SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

1 reference

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1 reference

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Preferential contribution of B7‐H1 to programmed death‐1‐mediated regulation of hapten‐specific allergic inflammatory responses

1 reference

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Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

1 reference

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1 reference

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

1 reference

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PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

1 reference

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B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells

1 reference

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

1 reference

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Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

1 reference

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The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

1 reference

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

1 reference

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Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies

1 reference

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B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1 reference

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

1 reference

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The immunological synapse: a molecular machine controlling T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371732

20 June 2018

Three-dimensional segregation of supramolecular activation clusters in T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3371732

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Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes

1 reference

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Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

1 reference

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1 reference

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

1 reference

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20 June 2018

B cell ligand discrimination through a spreading and contraction response.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20112741

21 January 2018

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20112741

21 January 2018

Structural and functional analysis of the costimulatory receptor programmed death-1.

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20112741

21 January 2018

Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20112741

21 January 2018

Identifiers

10.1084/JEM.20112741

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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