(Q46107625)

English

Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine

scientific article published on 29 January 2009

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scholarly article

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine (English)

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

1

object named as

Stella Manta

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

Dimitri Komiotis

8

object named as

Dimitri Komiotis

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

3

object named as

Niki Tzioumaki

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

author name string

Evangelia Tsoukala

2

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

Ales Goropevsek

4

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

Ravi Teja Pamulapati

5

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

Avrelija Cencic

6

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

Jan Balzarini

7

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

publication date

29 January 2009

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

European Journal of Medicinal Chemistry

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

44

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

6

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Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

2696-2704

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

Gemcitabine: metabolism, mechanisms of action, and self-potentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of sugar-modified cytosine nucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological activity of a fluorketonulceoside: 7-(3-deoxy-3-fluoro-beta-D-glycero-hex-2-enopyranosyl-4-ulose) theophylline

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleosides and nucleotides. 141. Chemical stability of a new antitumor nucleoside, 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine in alkaline medium: formation of 2'-C-cyano-2'-deoxy-1-beta-D-ribo-pentofuranosylcytosine and its antitum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships of 2'-fluoro-2',3'-unsaturated D-nucleosides as anti-HIV-1 agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unsaturated fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-4-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine and N(6)-benzoyl adenine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic Incorporation in DNA of 1,5-Anhydrohexitol Nucleotides†

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2'-Deoxy-2'-methylene derivatives of adenosine, guanosine, tubercidin, cytidine and uridine as inhibitors of L1210 cell growth in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and molecular modelling of unsaturated exomethylene pyranonucleoside analogues with antitumor and antiviral activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thymidylate synthase and drug resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions of cytostatic unsaturated ketonucleosides with sulfhydryl containing cell constituents

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA chain termination activity and inhibition of human immunodeficiency virus reverse transcriptase by carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine triphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the inhibition of the growth of KB cells by 9- and 7-(keto-nucleosides).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological effects of unsaturated ketonucleosides on eucaryotic cells in culture--the action of 7-(3',4'-unsaturated 2'-ketohexosyl) theophylline

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in resistance to 5-fluorouracil as a function of cell cycle delay and not apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total synthesis of quinine and quinidine. II

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiproliferative and apoptotic activities of ketonucleosides and keto-C-glycosides against non-small-cell lung cancer cells with intrinsic drug resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereoselective synthesis and antiviral activity of D-2',3'-didehydro-2',3'-dideoxy-2'-fluoro-4'-thionucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow cytometric analysis by bromodeoxyuridine/DNA assay of cell cycle perturbation of methotrexate-treated mouse L1210 leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perspectives on the molecular mechanism of inhibition and toxicity of nucleoside analogs that target HIV-1 reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorouracil: biochemistry and pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-2-keto-beta-D-glucopyranosyl derivatives of N4-benzoyl cytosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and function of S-adenosylhomocysteine hydrolase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exomethylene pyranonucleosides: efficient synthesis and biological evaluation of 1-(2,3,4-trideoxy-2-methylene-beta-d-glycero-hex-3-enopyranosyl)thymine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Antitumor effects of keto-nucleosides. Study of the antitumor activity of y(3'-O-acetyl-4', 6'-dideoxy-beta-L-glycero-hex-3'-eno-pyranosyl) theophylline and 1(4'-keto-2'-3'-O-isopropylidene-alpha-L-''rhamnosyl''O thymine against L 1210 leukemia in

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of (beta-L-fucopyranosulosyl)-7-theophylline on the growth of cells cultured in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-nucleosides: antiviral activity and molecular mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorinated nucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and antineoplastic properties of 3'-deoxy-3'-fluoroketonucleoside derivatives. Correlations between structure and biological activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of genotoxic effects in cells exposed to four ketonucleoside derivatives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, Biological Evaluation, and Structure Analysis of a Series of New 1,5-Anhydrohexitol Nucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluorinated Nucleosides: Synthesis and Biological Implication

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An efficient synthesis of 3-fluoro-5-thio-xylofuranosyl nucleosides of thymine, uracil, and 5-fluorouracil as potential antitumor or/and antiviral agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/19246130

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EJMECH.2009.01.020

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

0 references

1 reference

Europe PubMed Central

19 December 2017

http://europepmc.org/abstract/MED/19246130

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