(Q27640029)

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Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

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scholarly article

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Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism (English)

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Mycobacterium tuberculosis

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1

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7

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Hélène Munier-Lehmann

3

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Serge Van Calenbergh

object named as

Serge Van Calenbergh

6

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object named as

Piet Herdewijn

5

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author name string

Veerle Vanheusden

2

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Mattheus Froeyen

4

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language of work or name

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publication date

14 February 2003

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Journal of Biological Chemistry

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278

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7

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4963-71

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Mycobacterium tuberculosis: drug-resistance mechanisms.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

1 reference

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21 January 2018

Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods

1 reference

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21 January 2018

Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Detection, delineation, measurement and display of cavities in macromolecular structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Synthesis of aminoglycoside-modified oligonucleotides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Assay of dehydrogenases with an O2-consuming biosensor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

The CCP4 suite: programs for protein crystallography

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

An iso-random Bi Bi mechanism for adenylate kinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Sequence and structure classification of kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Calcium binding sites in tomato bushy stunt virus visualized by Laue crystallography

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Catalytic triads and their relatives

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

A novel combination of two classic catalytic schemes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Phosphoryl transfer by a concerted reaction mechanism in UMP/CMP-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Improved Fourier coefficients for maps using phases from partial structures with errors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Infectious disease. Drug-resistant TB on the rise

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Dialogue between Mycobacterium tuberculosis and Homo sapiens

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Improved spectrophotometric assay of nucleoside monophosphate kinase activity using the pyruvate kinase/lactate dehydrogenase coupling system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209630200

21 January 2018

Further additions to MolScript version 1.4, including reading and contouring of electron-density maps

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M209630200

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