(Q46124218)

19 December 2017

title

Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex (English)

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19 December 2017

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7

Arthur Weiss

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19 December 2017

author name string

Margaret D Myers

1

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19 December 2017

Tomasz Sosinowski

2

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19 December 2017

Leonard L Dragone

3

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19 December 2017

Carmen White

4

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19 December 2017

Hamid Band

5

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19 December 2017

Hua Gu

6

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19 December 2017

language of work or name

English

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publication date

4 December 2005

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19 December 2017

published in

Nature Immunology

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19 December 2017

volume

7

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19 December 2017

issue

1

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19 December 2017

page(s)

57-66

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19 December 2017

Regulation of thymocyte development: only the meek survive

cites work

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Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

21 January 2018

1 reference

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

21 January 2018

1 reference

Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes

21 January 2018

1 reference

Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation

21 January 2018

1 reference

Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase

21 January 2018

1 reference

Src-like adaptor protein (Slap) is a negative regulator of mitogenesis

21 January 2018

1 reference

Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling

21 January 2018

1 reference

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling

21 January 2018

1 reference

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

21 January 2018

1 reference

The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.

21 January 2018

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

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Regulating protein degradation by ubiquitination

21 January 2018

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T cell antigen receptor ubiquitination is a consequence of receptor-mediated tyrosine kinase activation

21 January 2018

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Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.

21 January 2018

1 reference

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

21 January 2018

1 reference

How many thymocytes audition for selection?

21 January 2018

1 reference

Signal transduction by the TCR for antigen

21 January 2018

1 reference

Essential role for ZAP-70 in both positive and negative selection of thymocytes

21 January 2018

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Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation

21 January 2018

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Inhibition of receptor-mediated but not fluid-phase endocytosis in polymorphonuclear leukocytes

21 January 2018

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Internalization of human T lymphocyte receptors

21 January 2018

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

21 January 2018

1 reference

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

21 January 2018

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Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling

21 January 2018

1 reference

ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells

21 January 2018

1 reference

T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization

21 January 2018

1 reference

Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

1 reference

Cbl-mediated ubiquitinylation and negative regulation of Vav.

21 January 2018

1 reference

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

21 January 2018

1 reference

Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling

21 January 2018

1 reference

Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling

21 January 2018

1 reference

A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling

21 January 2018

1 reference

The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation

21 January 2018

1 reference

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

21 January 2018

1 reference

Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.

21 January 2018

1 reference

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

21 January 2018

1 reference

Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line

21 January 2018

1 reference

Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

1 reference

The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells

21 January 2018

1 reference

The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

21 January 2018

1 reference

The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

21 January 2018

1 reference

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

1 reference

Activation-induced ubiquitination of the T cell antigen receptor

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Effect of hypertonicity and monensin on CD3/TCR surface expression in human T cells

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NI1291

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19 December 2017

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19 December 2017