(Q46134848)

19 December 2017

title

Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice (English)

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19 December 2017

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M Akiyama

1

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19 December 2017

M Hatanaka

2

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19 December 2017

Y Ohta

3

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19 December 2017

K Ueda

4

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19 December 2017

A Yanai

5

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19 December 2017

Y Uehara

6

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19 December 2017

K Tanabe

7

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19 December 2017

M Tsuru

8

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19 December 2017

M Miyazaki

9

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19 December 2017

S Saeki

10

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19 December 2017

T Saito

11

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19 December 2017

K Shinoda

12

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19 December 2017

Y Oka

13

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19 December 2017

Y Tanizawa

14

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19 December 2017

publication date

4 February 2009

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19 December 2017

published in

Diabetologia

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19 December 2017

volume

52

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19 December 2017

issue

4

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19 December 2017

page(s)

653-663

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19 December 2017

https://scigraph.springernature.com/pub.10.1007/s00125-009-1270-6

exact match

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cites work

Endoplasmic reticulum stress and N-glycosylation modulate expression of WFS1 protein

1 reference

12 December 2020

The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients.

1 reference

12 December 2020

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

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12 December 2020

Glucolipotoxicity: fuel excess and beta-cell dysfunction.

1 reference

12 December 2020

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

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12 December 2020

Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

1 reference

12 December 2020

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

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12 December 2020

Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta

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12 December 2020

The mammalian unfolded protein response

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12 December 2020

The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes

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12 December 2020

Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets.

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12 December 2020

Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: Possible protection of beta cells from oxidative stress

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12 December 2020

Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

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12 December 2020

The role for endoplasmic reticulum stress in diabetes mellitus

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12 December 2020

Physiological consequences of ectopic agouti gene expression: the yellow obese mouse syndrome

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12 December 2020

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

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12 December 2020

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

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12 December 2020

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

1 reference

12 December 2020

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

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12 December 2020

Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome

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12 December 2020

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells

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12 December 2020

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

1 reference

12 December 2020

Studies with antipeptide antibody suggest the presence of at least two types of glucose transporter in rat brain and adipocyte.

1 reference

12 December 2020

Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis

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12 December 2020

Signal integration in the endoplasmic reticulum unfolded protein response

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12 December 2020

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

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12 December 2020

WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum

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12 December 2020

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

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12 December 2020

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

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12 December 2020

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion

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12 December 2020

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

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12 December 2020

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells

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12 December 2020

Neurodegeneration and diabetes: UK nationwide study of Wolfram (DIDMOAD) syndrome.

1 reference

12 December 2020

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

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12 December 2020

Wolfram (DIDMOAD) syndrome.

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12 December 2020

ER stress and diseases.

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12 December 2020

Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway.

1 reference

12 December 2020

Type 2 diabetes-a matter of beta-cell life and death?

1 reference

12 December 2020

Pioglitazone attenuates fatty acid-induced oxidative stress and apoptosis in pancreatic beta-cells.

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12 December 2020

Pioglitazone preserves pancreatic islet structure and insulin secretory function in three murine models of type 2 diabetes

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12 December 2020

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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12 December 2020

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

1 reference

12 December 2020

Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells

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12 December 2020

Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation

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12 December 2020

Common variants in WFS1 confer risk of type 2 diabetes

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12 December 2020

A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC.

1 reference

12 December 2020

Sodium-potassium ATPase 1 subunit is a molecular partner of Wolframin, an endoplasmic reticulum protein involved in ER stress

1 reference

12 December 2020

Wolfram syndrome: structural and functional analyses of mutant and wild-type wolframin, the WFS1 gene product.

1 reference

12 December 2020

Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell

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12 December 2020

Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium

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12 December 2020

10.1007/S00125-009-1270-6

Identifiers

DOI

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19 December 2017

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19 December 2017