(Q46175385)

English

Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease

scientific article published on 4 January 2009

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scholarly article

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease (English)

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

Alzheimer's disease

0 references

cognitive dysfunction

1 reference

based on heuristic

inferred from title

author name string

Cai Zhiyou

1

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

Yan Yong

2

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

Sun Shanquan

3

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

Zhang Jun

4

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

Huang Liangguo

5

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

Yan Ling

6

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

Li Jieying

7

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

publication date

4 January 2009

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

Neurochemical Research

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

34

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

7

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

1226-1235

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

https://scigraph.springernature.com/pub.10.1007/s11064-008-9899-y

0 references

A renewed look at laboratory rodent housing and management

1 reference

https://api.crossref.org/works/10.1007%2FS11064-008-9899-Y

21 January 2018

Effects of acute and chronic physical exercise and stress on different types of memory in rats.

1 reference

https://api.crossref.org/works/10.1007%2FS11064-008-9899-Y

21 January 2018

Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes

1 reference

https://api.crossref.org/works/10.1007%2FS11064-008-9899-Y

21 January 2018

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

1 reference

https://api.crossref.org/works/10.1007%2FS11064-008-9899-Y

21 January 2018

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional interactions of tau and their relevance for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vicious cycles within the neuropathophysiologic mechanisms of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sialylation enhances the secretion of neurotoxic amyloid-beta peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular APP processing and A beta production in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Secretase, APP and Abeta in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic cerebral hypoperfusion elicits neuronal apoptosis and behavioral impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal nitric oxide upregulation precedes memory loss and A beta 1-40 accumulation after chronic brain hypoperfusion in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of the β-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment γ Are Potentiated by FE65L1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex translational regulation of BACE1 involves upstream AUGs and stimulatory elements within the 5' untranslated region

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation and pro-peptide cleavage of beta-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein-protein interactions in the assembly and subcellular trafficking of the BACE (beta-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angelica injection reduces cognitive impairment during chronic cerebral hypoperfusion through brain-derived neurotrophic factor and nerve growth factor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the beta-amyloid protein in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DDPH: improving cognitive deficits beyond its alpha 1-adrenoceptor antagonism in chronic cerebral hypoperfused rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 expression and activity: relevance in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic ischemia and neurocognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From tangles to tau protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta amyloidosis in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic reduction of cerebral blood flow in the adult rat: late-emerging CA1 cell loss and memory dysfunction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic ethanol intake-induced changes in open-field behavior and calcium/calmodulin-dependent protein kinase IV expression in nucleus accumbens of rats: naloxone reversal

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrovascular hypoperfusion: a risk factor for Alzheimer's disease? Animal model and postmortem human studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Alzheimer's disease: cardiovascular risk factors must be assessed].

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessment of spatial memory using the radial arm maze and Morris water maze

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE/APPV717F double-transgenic mice develop cerebral amyloidosis and inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ameliorative influence of a nootropic drug on motor activity of rats after bilateral carotid artery occlusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE2 functions as an alternative alpha-secretase in cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A guide to production, care and use of laboratory animals. An annotated bibliography. 1. Normal anatomy, physiology, psychology, including the role of factors in the environment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paired helical filament morphology varies with intracellular location in Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of cilostazol against transient focal cerebral ischemia and chronic cerebral hypoperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of amyloid-beta-peptide generation by subcellular trafficking of the beta-amyloid precursor protein and beta-secretase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[The role of chronic brain hypoperfusion in the pathogenesis of Alzheimer's disease--facts and hypotheses].

1 reference

https://pubmed.ncbi.nlm.nih.gov/19123057

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11064-008-9899-Y

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19123057

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