(Q28307707)

1

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Evelina Chieregatti

object named as

Evelina Chieregatti

2

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author name string

Barbara Bettegazzi

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Vitor Lino Sousa

5

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Fabio Grohovaz

6

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Jacopo Meldolesi

Neurodegenerative Diseases

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language of work or name

English

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publication date

2007

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published in

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volume

4

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issue

2-3

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page(s)

117-26

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cites work

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation

21 January 2018

1 reference

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

21 January 2018

1 reference

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

21 January 2018

1 reference

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

21 January 2018

1 reference

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

1 reference

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

21 January 2018

1 reference

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

21 January 2018

1 reference

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 January 2018

1 reference

BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

1 reference

Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells

21 January 2018

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge

21 January 2018

1 reference

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

21 January 2018

1 reference

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

21 January 2018

1 reference

alpha- and beta-secretase: profound changes in Alzheimer's disease.

21 January 2018

1 reference

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

1 reference

Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus

21 January 2018

1 reference

Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

21 January 2018

1 reference

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 January 2018

1 reference

Oxidative stress increases expression and activity of BACE in NT2 neurons

21 January 2018

1 reference

Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

21 January 2018

1 reference

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

21 January 2018

1 reference

Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

21 January 2018

1 reference

Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent

21 January 2018

1 reference

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

21 January 2018

1 reference

Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation

21 January 2018

1 reference

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

21 January 2018

1 reference

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

21 January 2018

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Human BACE forms dimers and colocalizes with APP.

21 January 2018

1 reference

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

21 January 2018

1 reference

APP processing and synaptic function

21 January 2018

1 reference

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

21 January 2018

1 reference

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

1 reference

Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro

21 January 2018

1 reference

Elevated low-density lipoprotein in Alzheimer's disease correlates with brain abeta 1-42 levels.

21 January 2018

1 reference

The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

Cholesterol, statins and dementia.

21 January 2018

1 reference

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

1 reference

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

Relation of plasma lipids to Alzheimer disease and vascular dementia

21 January 2018

1 reference

Neuronal membrane cholesterol loss enhances amyloid peptide generation

21 January 2018

1 reference

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

The conflicting role of brain cholesterol in Alzheimer's disease: lessons from the brain plasminogen system

21 January 2018

1 reference