(Q46178511)

20 December 2017

title

Hoxa9 collaborates with E2A-PBX1 in mouse B cell leukemia in association with Flt3 activation and decrease of B cell gene expression (English)

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20 December 2017

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9

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20 December 2017

Daniel Sinnett

object named as

Daniel Sinnett

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author name string

Mona Hassawi

1

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20 December 2017

Elena A Shestakova

2

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20 December 2017

Marilaine Fournier

3

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20 December 2017

Charles-Étienne Lebert-Ghali

4

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20 December 2017

Gratianne Vaisson

5

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20 December 2017

Héloïse Frison

6

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20 December 2017

Ramon Vidal

8

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20 December 2017

Janet J Bijl

10

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20 December 2017

publication date

7 October 2013

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20 December 2017

published in

Developmental Dynamics

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20 December 2017

volume

243

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20 December 2017

issue

1

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20 December 2017

page(s)

145-158

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20 December 2017

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

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E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells

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Critical role for a single leucine residue in leukemia induction by E2A-PBX1

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Pbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus

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The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis

21 January 2018

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Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins

21 January 2018

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Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis

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The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1.

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Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.

21 January 2018

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HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo

21 January 2018

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HOXA4 induces expansion of hematopoietic stem cells in vitro and confers enhancement of pro-B-cells in vivo.

21 January 2018

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Hoxa9 regulates Flt3 in lymphohematopoietic progenitors

21 January 2018

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Identification and characterization of Hoxa9 binding sites in hematopoietic cells

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E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice

21 January 2018

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The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials

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A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL

21 January 2018

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

21 January 2018

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Heterodimerization of Hox proteins with Pbx1 and oncoprotein E2a-Pbx1 generates unique DNA-binding specifities at nucleotides predicted to contact the N-terminal arm of the Hox homeodomain--demonstration of Hox-dependent targeting of E2a-Pbx1 in viv

21 January 2018

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Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

21 January 2018

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Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation

21 January 2018

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Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development

21 January 2018

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Retroviral gene transfer using safe and efficient packaging cell lines

21 January 2018

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Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis

21 January 2018

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Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia

21 January 2018

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Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable

21 January 2018

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Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

21 January 2018

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Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif

21 January 2018

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E protein function in lymphocyte development

21 January 2018

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Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

21 January 2018

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21 January 2018

1 reference

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Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.24056

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.24056

Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation

21 January 2018

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WNT signalling and haematopoiesis: a WNT-WNT situation

21 January 2018

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E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause acute T-lymphoid or myeloid leukemias in mice

21 January 2018

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Global down-regulation of HOX gene expression in PML-RARalpha + acute promyelocytic leukemia identified by small-array real-time PCR.

21 January 2018

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Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

21 January 2018

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The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells

21 January 2018

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Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

21 January 2018

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Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

21 January 2018

1 reference

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Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia

21 January 2018

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Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

21 January 2018

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C/EBPα and MYB regulate FLT3 expression in AML

21 January 2018

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Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes

21 January 2018

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The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

21 January 2018

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Evidence for Hox and E2A-PBX1 collaboration in mouse T-cell leukemia

21 January 2018

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7 January 2021

HoxA cluster is haploinsufficient for activity of hematopoietic stem and progenitor cells

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.24056

7 January 2021

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.24056

7 January 2021

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.24056

7 January 2021

Identifiers

DOI

10.1002/DVDY.24056

1 reference

20 December 2017

PubMed ID

23996689

1 reference

20 December 2017