(Q46211455)

20 December 2017

title

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation (English)

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20 December 2017

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Benedict Seddon

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Victor Tybulewicz

object named as

Victor Tybulewicz

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author name string

Srividya Sriskantharajah

1

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20 December 2017

Monica P Belich

2

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20 December 2017

Stamatia Papoutsopoulou

3

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20 December 2017

Julia Janzen

4

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20 December 2017

Steven C Ley

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20 December 2017

language of work or name

English

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publication date

7 December 2008

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20 December 2017

published in

Nature Immunology

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20 December 2017

volume

10

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20 December 2017

page(s)

38-47

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20 December 2017

issue

1

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20 December 2017

Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain

cites work

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Interleukin-2 receptor signaling in regulatory T cell development and homeostasis

21 January 2018

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I kappa B kinase 2/beta deficiency controls expansion of autoreactive T cells and suppresses experimental autoimmune encephalomyelitis.

21 January 2018

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I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion.

21 January 2018

1 reference

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

21 January 2018

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A fourth IkappaB protein within the NF-kappaB signaling module

21 January 2018

1 reference

12 December 2020

Mature T cells depend on signaling through the IKK complex.

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12 December 2020

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

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12 December 2020

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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12 December 2020

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12 December 2020

The precursor of NF-kappa B p50 has I kappa B-like functions

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12 December 2020

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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12 December 2020

Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules

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12 December 2020

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

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12 December 2020

The NF-kappa B p50 precursor, p105, contains an internal I kappa B-like inhibitor that preferentially inhibits p50

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12 December 2020

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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12 December 2020

ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability

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12 December 2020

ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses

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12 December 2020

Structure, regulation and function of NF-kappa B

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12 December 2020

MAP kinase kinase kinases and innate immunity

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12 December 2020

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

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12 December 2020

IkappaB kinase is an essential component of the Tpl2 signaling pathway

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12 December 2020

NF-kappa B/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells

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12 December 2020

Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues

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12 December 2020

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

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12 December 2020

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

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12 December 2020

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

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12 December 2020

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

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12 December 2020

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2

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12 December 2020

In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells

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12 December 2020

NF-kappaB regulation in the immune system

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12 December 2020

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

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12 December 2020

In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers

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12 December 2020

The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B

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12 December 2020

Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function

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12 December 2020

Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50.

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12 December 2020

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

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12 December 2020

Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.

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12 December 2020

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction

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12 December 2020

Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells

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12 December 2020

Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology

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12 December 2020

p105.Ikappa Bgamma and prototypical Ikappa Bs use a similar mechanism to bind but a different mechanism to regulate the subcellular localization of NF-kappa B.

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12 December 2020

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

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12 December 2020

Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis

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12 December 2020

Identifiers

DOI

10.1038/NI.1685

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20 December 2017

PubMed ID

19060899

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20 December 2017