(Q46223004)

English

Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch

scientific article published on 4 June 2012

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

1 reference

based on heuristic

inferred from title

author name string

Y Ishikawa

1

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

M Hosogane

2

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

R Okuyama

3

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

S Aoyama

4

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

I Onoyama

5

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

K I Nakayama

6

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

K Nakayama

7

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

language of work or name

0 references

publication date

4 June 2012

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

32

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

15

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

1921-1932

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

Ubiquitin ligases: cell-cycle control and cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Systematic analysis and nomenclature of mammalian F-box proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

SCF-mediated protein degradation and cell cycle control

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Notch and cancer: a double-edged sword

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Notch1 functions as a tumor suppressor in mouse skin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Myc lacks E2F1's ability to suppress skin carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Contribution of stem cells and differentiated cells to epidermal tumours

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Skin stem cells: rising to the surface

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Cell size as a determinant of the clone-forming ability of human keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

p53 homologue, p51/p63, maintains the immaturity of keratinocyte stem cells by inhibiting Notch1 activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

p63 Is essential for the proliferative potential of stem cells in stratified epithelia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Stem cell depletion through epidermal deletion of Rac1.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Developmental biology. Rac1 up for epidermal stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

Plat-E: an efficient and stable system for transient packaging of retroviruses

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

21 January 2018

The Fbxw7/hCdc4 tumor suppressor in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

31 March 2020

Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

31 March 2020

AP-2alpha Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.213

31 March 2020

Identifiers

10.1038/ONC.2012.213

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/22665065

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q46223004&oldid=2207727158"