(Q46237585)

http://europepmc.org/abstract/MED/19020024

20 December 2017

title

Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria (English)

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http://europepmc.org/abstract/MED/19020024

20 December 2017

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

Melanie Ott

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

author name string

Ken Nakamura

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

Erika K Wallender

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

Robert H Edwards

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

Katrin Kaehlcke

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

language of work or name

English

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publication date

1 November 2008

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http://europepmc.org/abstract/MED/19020024

20 December 2017

published in

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

volume

28

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

issue

47

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

page(s)

12305-12317

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein

16 May 2020

cites work

1 reference

12 December 2020

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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12 December 2020

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

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12 December 2020

Purification of mitochondria for apoptosis assays

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12 December 2020

alpha-synuclein promotes mitochondrial deficit and oxidative stress

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12 December 2020

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

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12 December 2020

Förster distances between green fluorescent protein pairs.

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12 December 2020

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

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12 December 2020

Fluorescent labeling of recombinant proteins in living cells with FlAsH.

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12 December 2020

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

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12 December 2020

Conformational properties of alpha-synuclein in its free and lipid-associated states

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12 December 2020

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

1 reference

12 December 2020

Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons

1 reference

12 December 2020

Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

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12 December 2020

Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

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12 December 2020

Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein

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12 December 2020

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

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12 December 2020

Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer

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12 December 2020

Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells

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12 December 2020

Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment

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12 December 2020

Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.

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12 December 2020

Regulation of alpha-synuclein by bFGF in cultured ventral midbrain dopaminergic neurons

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12 December 2020

A broken alpha -helix in folded alpha -Synuclein

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12 December 2020

The C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylation

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12 December 2020

Lipid binding inhibits alpha-synuclein fibril formation

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12 December 2020

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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12 December 2020

Phospholipid scramblase 3 controls mitochondrial structure, function, and apoptotic response

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12 December 2020

Mapping of Rat Brain Using the Synuclein-1 Monoclonal Antibody Reveals Somatodendritic Expression of α-Synuclein in Populations of Neurons Homologous to those Vulnerable to Lewy Body Formation in Human Synucleopathies

1 reference

12 December 2020

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

12 December 2020

A Rapid Cellular FRET Assay of Polyglutamine Aggregation Identifies a Novel Inhibitor

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12 December 2020

Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo

1 reference

12 December 2020

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

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12 December 2020

Yeast cells provide insight into alpha-synuclein biology and pathobiology

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12 December 2020

Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling

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12 December 2020

A critical intramolecular interaction for protein kinase Cepsilon translocation

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12 December 2020

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

12 December 2020

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

12 December 2020

Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein

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12 December 2020

Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling

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12 December 2020

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

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12 December 2020

Lipid rafts mediate the synaptic localization of alpha-synuclein.

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12 December 2020

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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12 December 2020

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

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12 December 2020

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

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12 December 2020

SIRT1 regulates HIV transcription via Tat deacetylation

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12 December 2020

A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells

1 reference

12 December 2020

Alpha-synuclein expression in the substantia nigra of MPTP-lesioned non-human primates

1 reference

12 December 2020

A combinatorial code for the interaction of alpha-synuclein with membranes

1 reference

12 December 2020

Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation

1 reference

12 December 2020

Effect of pH on thermal- and chemical-induced denaturation of GFP.

1 reference

12 December 2020

Characterization of oligomeric intermediates in alpha-synuclein fibrillation: FRET studies of Y125W/Y133F/Y136F alpha-synuclein

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12 December 2020

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

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12 December 2020

Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein

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12 December 2020

Mice lacking alpha-synuclein are resistant to mitochondrial toxins

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12 December 2020

Neural activity controls the synaptic accumulation of alpha-synuclein.

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12 December 2020

Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.

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12 December 2020

ATP synthase is responsible for maintaining mitochondrial membrane potential in bloodstream form Trypanosoma brucei

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12 December 2020

Temperature-induced reversible conformational change in the first 100 residues of alpha-synuclein

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12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

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12 December 2020

Secondary structure and dynamics of micelle bound beta- and gamma-synuclein

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12 December 2020

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

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12 December 2020

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

1 reference

12 December 2020

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

1 reference

12 December 2020

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

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12 December 2020

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 reference

12 December 2020

Relationship among alpha-synuclein accumulation, dopamine synthesis, and neurodegeneration in Parkinson disease substantia nigra.

1 reference

12 December 2020

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

1 reference

12 December 2020

Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity

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12 December 2020

Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage

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12 December 2020

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.

1 reference

12 December 2020

Localization of alpha-synuclein to mitochondria within midbrain of mice

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12 December 2020

Rational design and evaluation of FRET experiments to measure protein proximities in cells

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12 December 2020

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

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12 December 2020

Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification

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12 December 2020

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

1 reference

12 December 2020

Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody

1 reference

12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

12 December 2020

Lipids of mitochondria

1 reference

12 December 2020

Lipid topology and physical properties of the outer mitochondrial membrane of the yeast, Saccharomyces cerevisiae

1 reference

12 December 2020

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1 reference

12 December 2020

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

1 reference

12 December 2020

The when and how of Src regulation

1 reference

12 December 2020

Phospholipid asymmetry of the outer membrane of rat liver mitochondria

1 reference

12 December 2020

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

12 December 2020

Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons

1 reference

12 December 2020

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

12 December 2020

Alpha-synuclein in Lewy bodies

1 reference

12 December 2020

4E binding proteins inhibit the translation factor eIF4E without folded structure

1 reference

12 December 2020

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

12 December 2020

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

1 reference

12 December 2020

Three-dimensional structure and composition of CA3-->CA1 axons in rat hippocampal slices: implications for presynaptic connectivity and compartmentalization.

1 reference

12 December 2020

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

1 reference

12 December 2020

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

1 reference

12 December 2020

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

1 reference

12 December 2020

10.1523/JNEUROSCI.3088-08.2008

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671709&resulttype=core&format=json

16 May 2020

1 reference