(Q46289616)

English

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei

scientific article published on 13 August 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Trypanosoma brucei

0 references

1 reference

Actinosynnema mirum

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

Jair Siqueira-Neto

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Roger G Linington

9

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Michael A. Fischbach

object named as

Michael A Fischbach

8

0 references

James H McKerrow

7

object named as

James H McKerrow

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Mohamed S. Donia

2

object named as

Mohamed S Donia

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

author name string

Christopher J Schulze

1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Debalina Ray

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Jevgenij A Raskatov

5

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Richard E Green

6

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

publication date

13 August 2015

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

ACS Chemical Biology

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

10

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

10

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

2373-2381

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

online access status

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1021/acschembio.5b00308?email=unpaywall_01@example.com

access restriction status

1 reference

based on heuristic

inferred from online access status

Micromonosporin A, a novel 24-membered polyene lactam macrolide from Micromonospora sp. isolated from peat swamp forest

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete genome sequence of Actinosynnema mirum type strain (101).

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new macrocyclic lactam antibiotic, BE-14106. I. Taxonomy, isolation, biological activity and structural elucidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural products version 2.0: connecting genes to molecules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation, Structure Elucidation, and Biosynthesis of an Unusual Hydroxamic Acid Ester-Containing Siderophore from Actinosynnema mirum

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000-2009: the way forward

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug discovery and development for neglected diseases: the DNDi model

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the incednine biosynthetic gene cluster: characterization of novel β-glutamate-β-decarboxylase IdnL3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies for the discovery of new natural products by genome mining

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Full Stereochemical Determination of Ajudazols A and B by Bioinformatics Gene Cluster Analysis and Total Synthesis of Ajudazol B by an Asymmetric Ortholithiation Strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp. GB 4-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A tylosin ketoreductase reveals how chirality is determined in polyketides

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of gene cluster for mycosporine-like amino acid biosynthesis from Actinomycetales microorganisms and production of a novel mycosporine-like amino acid by heterologous expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanocidal activity of marine natural products

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomics-inspired discovery of natural products

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Unique Pathway for the 3-Aminobutyrate Starter Unit from l-Glutamate through β-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of micromonolactam, a new polyene macrocyclic lactam from two marine Micromonospora strains using chemical and molecular methods: clarification of the biosynthetic pathway from a glutamate starter unit

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane activity of the pentaene macrolide didehydroroflamycoin in model lipid bilayers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp. Tü 6392*.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lepadins D-F: antiplasmodial and antitrypanosomal decahydroquinoline derivatives from the tropical marine tunicate Didemnum sp.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitrypanosomal cyclic polyketide peroxides from the Australian marine sponge Plakortis sp.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of incednine as a potent modulator of the anti-apoptotic function of Bcl-xL from microbial origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chivosazole A--elucidation of the absolute and relative configuration

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actinosynnema mirum, a new producer of nocardicin antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aureoverticillactam, a novel 22-atom macrocyclic lactam from the marine actinomycete Streptomyces aureoverticillatus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lessons from the past and charting the future of marine natural products drug discovery and chemical biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Neglected disease research and development: how much are we really spending?

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Do we need new drugs against human African trypanosomiasis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACSCHEMBIO.5B00308

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

ResearchGate publication ID

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