(Q46289616)

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Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei

scientific article published on 13 August 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Trypanosoma brucei

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1 reference

Actinosynnema mirum

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

Jair Siqueira-Neto

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Roger G Linington

9

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Michael A. Fischbach

object named as

Michael A Fischbach

8

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James H McKerrow

7

object named as

James H McKerrow

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Mohamed S. Donia

2

object named as

Mohamed S Donia

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

author name string

Christopher J Schulze

1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Debalina Ray

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Jevgenij A Raskatov

5

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

Richard E Green

6

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

publication date

13 August 2015

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

ACS Chemical Biology

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

10

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

10

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

2373-2381

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

online access status

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1021/acschembio.5b00308?email=unpaywall_01@example.com

access restriction status

1 reference

based on heuristic

inferred from online access status

Micromonosporin A, a novel 24-membered polyene lactam macrolide from Micromonospora sp. isolated from peat swamp forest

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

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Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Assembly and absolute configuration of short-lived polyketides from Burkholderia thailandensis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Complete genome sequence of Actinosynnema mirum type strain (101).

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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A new macrocyclic lactam antibiotic, BE-14106. I. Taxonomy, isolation, biological activity and structural elucidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Natural products version 2.0: connecting genes to molecules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Isolation, Structure Elucidation, and Biosynthesis of an Unusual Hydroxamic Acid Ester-Containing Siderophore from Actinosynnema mirum

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Molecular Basis of Celmer's Rules: Stereochemistry of Catalysis by Isolated Ketoreductase Domains from Modular Polyketide Synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000-2009: the way forward

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Drug discovery and development for neglected diseases: the DNDi model

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the incednine biosynthetic gene cluster: characterization of novel β-glutamate-β-decarboxylase IdnL3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies for the discovery of new natural products by genome mining

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Full Stereochemical Determination of Ajudazols A and B by Bioinformatics Gene Cluster Analysis and Total Synthesis of Ajudazol B by an Asymmetric Ortholithiation Strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Piceamycin and its N-acetylcysteine adduct is produced by Streptomyces sp. GB 4-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A tylosin ketoreductase reveals how chirality is determined in polyketides

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

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Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

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Discovery of gene cluster for mycosporine-like amino acid biosynthesis from Actinomycetales microorganisms and production of a novel mycosporine-like amino acid by heterologous expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Trypanocidal activity of marine natural products

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomics-inspired discovery of natural products

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Unique Pathway for the 3-Aminobutyrate Starter Unit from l-Glutamate through β-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Identification of micromonolactam, a new polyene macrocyclic lactam from two marine Micromonospora strains using chemical and molecular methods: clarification of the biosynthetic pathway from a glutamate starter unit

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Insights into the evolution of macrolactam biosynthesis through cloning and comparative analysis of the biosynthetic gene cluster for a novel macrocyclic lactam, ML-449

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Membrane activity of the pentaene macrolide didehydroroflamycoin in model lipid bilayers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silvalactam, a 24-membered macrolactam antibiotic produced by Streptomyces sp. Tü 6392*.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

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Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness

1 reference

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Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

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Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

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Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Lepadins D-F: antiplasmodial and antitrypanosomal decahydroquinoline derivatives from the tropical marine tunicate Didemnum sp.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

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Conserved amino acid residues correlating with ketoreductase stereospecificity in modular polyketide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Antitrypanosomal cyclic polyketide peroxides from the Australian marine sponge Plakortis sp.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Discovery of incednine as a potent modulator of the anti-apoptotic function of Bcl-xL from microbial origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Chivosazole A--elucidation of the absolute and relative configuration

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actinosynnema mirum, a new producer of nocardicin antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Aureoverticillactam, a novel 22-atom macrocyclic lactam from the marine actinomycete Streptomyces aureoverticillatus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

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Lessons from the past and charting the future of marine natural products drug discovery and chemical biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

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Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis

1 reference

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Neglected disease research and development: how much are we really spending?

1 reference

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Do we need new drugs against human African trypanosomiasis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

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Vicenistatin, a novel 20-membered macrocyclic lactam antitumor antibiotic

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

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"Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/26270237

12 December 2020

based on heuristic

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Identifiers

10.1021/ACSCHEMBIO.5B00308

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/26270237

ResearchGate publication ID

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