(Q46289705)

21 December 2017

title

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy (English)

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21 December 2017

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Kareen Bartsch

1

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21 December 2017

Katharina Knittler

2

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21 December 2017

Christopher Borowski

3

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21 December 2017

Sönke Rudnik

4

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21 December 2017

Markus Damme

5

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21 December 2017

Konrad Aden

6

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21 December 2017

Martina E Spehlmann

7

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21 December 2017

Norbert Frey

8

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21 December 2017

Paul Saftig

9

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21 December 2017

Athena Chalaris

10

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21 December 2017

Björn Rabe

11

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21 December 2017

publication date

1 October 2017

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21 December 2017

published in

Human Molecular Genetics

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21 December 2017

volume

26

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21 December 2017

page(s)

3960-3972

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21 December 2017

issue

20

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21 December 2017

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Aicardi-Goutières syndrome and the type I interferonopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Ribonuclease H2 in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Ribonuclease H: the enzymes in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

The DNA damage response induces IFN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Inflammation-driven carcinogenesis is mediated through STING

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

STING: infection, inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Aicardi-Goutières syndrome: clues from the RNase H2 knock-out mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

The enemy within: endogenous retroelements and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Autophagy in infection, inflammation, and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Extracellular M. tuberculosis DNA targets bacteria for autophagy by activating the host DNA-sensing pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Nucleic acid-mediated inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Catastrophic nuclear envelope collapse in cancer cell micronuclei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

TREX1 deficiency triggers cell-autonomous immunity in a cGAS-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Chromothripsis and Kataegis Induced by Telomere Crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

SAMHD1 prevents autoimmunity by maintaining genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

DNA repair deficiency and neurological disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Reversal of peripheral and central neural storage and ataxia after recombinant enzyme replacement therapy in alpha-mannosidosis mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Genome engineering using the CRISPR-Cas9 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Characterization of L1 retrotransposition with high-throughput dual-luciferase assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

Determination of L1 retrotransposition kinetics in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

LINE-mediated retrotransposition of marked Alu sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDX283

21 January 2018

Identifiers

DOI

10.1093/HMG/DDX283

1 reference

21 December 2017

PubMed ID

29016854

1 reference

21 December 2017