(Q34719398)

4 August 2017

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease (English)

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Three prime repair exonuclease 1

4 August 2017

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1 reference

GOA release 2020-03-11

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2

Tomas Lindahl

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4 August 2017

Yun-Gui Yang

1

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4 August 2017

Deborah E Barnes

series ordinal

3

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4 August 2017

language of work or name

English

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publication date

1 November 2007

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4 August 2017

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4 August 2017

131

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4 August 2017

873-886

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4 August 2017

5

1 reference

describes a project that uses

4 August 2017

Trex1-/- MEF

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cites work

ATR and ATRIP: partners in checkpoint signaling

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.1065521

Saccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nuclease

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/citations/10.1128/MCB.19.12.8361

A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/citations/10.1093/EMBOJ/18.13.3868

gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Biochemical analysis of human Dna2

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Reconstituted Okazaki fragment processing indicates two pathways of primer removal

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Creation and removal of embedded ribonucleotides in chromosomal DNA during mammalian Okazaki fragment processing

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Isolation of human Dna2 endonuclease and characterization of its enzymatic properties

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Aicardi-Goutières syndrome: an update and results of interferon-alpha studies

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Discrete sizes of replication intermediates in Drosophila cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

The absence of ribonuclease H1 or H2 alters the sensitivity of Saccharomyces cerevisiae to hydroxyurea, caffeine and ethyl methanesulphonate: implications for roles of RNases H in DNA replication and repair

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Nucleic acid by-products and chronic inflammation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Structure and expression of the TREX1 and TREX2 3' --> 5' exonuclease genes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Clinical and molecular phenotype of Aicardi-Goutieres syndrome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Long regions of single-stranded DNA in human cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

WAF1, a potential mediator of p53 tumor suppression

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

ATM and ATR: components of an integrated circuit

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

"ATR activation in response to ionizing radiation: still ATM territory".

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

DNA damage checkpoints in mammals

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Systemic Lupus Erythematosus or Aicardi-Goutières Syndrome?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Type I interferon in systemic lupus erythematosus and other autoimmune diseases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Exo1 processes stalled replication forks and counteracts fork reversal in checkpoint-defective cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

The DNA damage response, immunity and cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Innate immune recognition of, and regulation by, DNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Substrate specificity of human RNase H1 and its role in excision repair of ribose residues misincorporated in DNA

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

The Chk2 protein kinase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Sensing the enemy within

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Type I interferons in host defense

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Resistance of 3'-phosphoglycolate DNA ends to digestion by mammalian DNase III.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Surviving the breakup: the DNA damage checkpoint.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CELL.2007.10.017

Identifiers

DOI

10.1016/J.CELL.2007.10.017

1 reference

4 August 2017

1 reference