(Q46308032)

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Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18936756

Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples (English)

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18936756

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Stephanie Le Hellard

1

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http://europepmc.org/abstract/MED/18936756

Thomas F. Hansen

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http://europepmc.org/abstract/MED/18936756

Markus M Nöthen

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http://europepmc.org/abstract/MED/18936756

Ole A. Andreassen

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http://europepmc.org/abstract/MED/18936756

Alexander Georgi

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A Georgi

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S Cichon

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Srdjan Djurovic

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S Djurovic

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I Melle

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T Werge

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Marcella Rietschel

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M Rietschel

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I Nenadic

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V M Steen

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T W Mühleisen

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J Fernø

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Z Ouriaghi

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C Vasilescu

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M B Raeder

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http://europepmc.org/abstract/MED/18936756

J Strohmaier

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F F Brockschmidt

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H Sauer

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21 October 2008

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http://europepmc.org/abstract/MED/18936756

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Molecular Psychiatry

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http://europepmc.org/abstract/MED/18936756

15

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http://europepmc.org/abstract/MED/18936756

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463-472

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https://scigraph.springernature.com/pub.10.1038/mp.2008.110

0 references

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White matter changes in schizophrenia: evidence for myelin-related dysfunction

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Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?

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Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs

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Regulation of gene expression by SREBP and SCAP.

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Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

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Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

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The structure of haplotype blocks in the human genome

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Germ-line DNA copy number variation frequencies in a large North American population

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Detection of large-scale variation in the human genome

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Brain expressed microRNAs implicated in schizophrenia etiology

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Interaction between SREBP-1a and APOB polymorphisms influences total and low-density lipoprotein cholesterol levels in patients with coronary artery disease

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Effects of SREBF-1a and SCAP polymorphisms on plasma levels of lipids, severity, progression and regression of coronary atherosclerosis and response to therapy with fluvastatin

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Evidence for two schizophrenia susceptibility genes on chromosome 22q13.

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Electron microscopic study on schizophrenia. Mechanism of pathological changes.

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Electron microscopy of oligodendroglia in severe mental illness.

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Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium.

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MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia.

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Diffusion tensor imaging in schizophrenia

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Evidence for white matter abnormalities in schizophrenia

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Proton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia.

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Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study.

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Increase in gray matter and decrease in white matter volumes in the cortex during treatment with atypical neuroleptics in schizophrenia

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Oligodendrocyte dysfunction in schizophrenia and bipolar disorder

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Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia

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Variations in myelin and oligodendrocyte-related gene expression across multiple brain regions in schizophrenia: a gene ontology study

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Ontogeny of the human central nervous system: what is happening when?

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High cholesterol level is essential for myelin membrane growth

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Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

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Local regulation of fat metabolism in peripheral nerves

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Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia

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Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells

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SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts

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SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects?

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10.1038/MP.2008.110

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18936756

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18936756

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