(Q46324883)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28782796%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

Combination of traditional mutation and metabolic engineering to enhance ansamitocin P-3 production in Actinosynnema pretiosum (English)

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26 March 2020

5

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26 March 2020

Zhi-Qiang Du

1

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26 March 2020

author name string

Yuan Zhang

2

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26 March 2020

Zhi-Gang Qian

3

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26 March 2020

Han Xiao

4

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26 March 2020

language of work or name

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23 August 2017

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Biotechnology and Bioengineering

26 March 2020

published in

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26 March 2020

volume

114

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26 March 2020

issue

12

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26 March 2020

page(s)

2794-2806

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Regulation of secondary metabolism in streptomycetes

26 March 2020

cites work

1 reference

Process optimization with alternative carbon sources and modulation of secondary metabolism for enhanced ansamitocin P-3 production in Actinosynnema pretiosum.

21 January 2018

1 reference

Effects of modulation of pentose-phosphate pathway on biosynthesis of ansamitocins in Actinosynnema pretiosum.

21 January 2018

1 reference

Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnem pretiosum.

21 January 2018

1 reference

Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose.

21 January 2018

1 reference

Identification of avermectin-high-producing strains by high-throughput screening methods.

21 January 2018

1 reference

An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis.

21 January 2018

1 reference

Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517.

21 January 2018

1 reference

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.

21 January 2018

1 reference

Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives

21 January 2018

1 reference

Engineering a functional 1-deoxy-D-xylulose 5-phosphate (DXP) pathway in Saccharomyces cerevisiae

21 January 2018

1 reference

Engineering antibiotic producers to overcome the limitations of classical strain improvement programs

21 January 2018

1 reference

Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum.

21 January 2018

1 reference

Improvement of ansamitocin P-3 production by Actinosynnema mirum with fructose as the sole carbon source.

21 January 2018

1 reference

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

1 reference

Constitutive overexpression of asm2 and asm39 increases AP-3 production in the actinomycete Actinosynnema pretiosum.

21 January 2018

1 reference

Triggering respirofermentative metabolism in the crabtree-negative yeast Pichia guilliermondii by disrupting the CAT8 gene.

21 January 2018

1 reference

Effect of rpoS gene knockout on the metabolism of Escherichia coli during exponential growth phase and early stationary phase based on gene expressions, enzyme activities and intracellular metabolite concentrations

21 January 2018

1 reference

Engineering of chromosomal wax ester synthase integrated Saccharomyces cerevisiae mutants for improved biosynthesis of fatty acid ethyl esters.

21 January 2018

1 reference

Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography-mass spectrometry.

21 January 2018

1 reference

Bioproduction of Antibody-Drug Conjugate Payload Precursors by Engineered Cell Factories.

21 January 2018

1 reference

Enhanced FK506 production in Streptomyces tsukubaensis by rational feeding strategies based on comparative metabolic profiling analysis.

21 January 2018

1 reference

The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum

21 January 2018

1 reference

Effects of the Methylmalonyl-CoA Metabolic Pathway on Ansamitocin Production in Actinosynnema pretiosum.

21 January 2018

1 reference

Generation of high rapamycin producing strain via rational metabolic pathway-based mutagenesis and further titer improvement with fed-batch bioprocess optimization.

21 January 2018

1 reference

Enhanced production of ansamitocin P-3 by addition of Mg2+ in fermentation of Actinosynnema pretiosum

21 January 2018

1 reference

Effect of ammonium in medium on ansamitocin P-3 production by Actinosynnema pretiosum

21 January 2018

1 reference

Enhanced production of ansamitocin P-3 by addition of isobutanol in fermentation of Actinosynnema pretiosum

21 January 2018

1 reference

Ansamitocin, a group of novel maytansinoid antibiotics with antitumour properties from Nocardia

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/BIT.26396

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28782796%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

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