(Q46347911)

9 July 2018

review article

1 reference

title

Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells (English)

1 reference

9 July 2018

author

Martin Kampmann

series ordinal

1

1 reference

PubMed publication ID

28487920

21 December 2017

http://europepmc.org/abstract/MED/28487920

language of work or name

English

0 references

publication date

1 June 2017

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9 July 2018

published in

Chemical Communications

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9 July 2018

volume

53

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9 July 2018

issue

53

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9 July 2018

page(s)

7162-7167

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9 July 2018

Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia

cites work

1 reference

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Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Next-generation libraries for robust RNA interference-based genome-wide screens.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Unraveling the mechanism of cell death induced by chemical fibrils

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Genome-scale CRISPR-Cas9 knockout screening in human cells

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Genetic screens in human cells using the CRISPR-Cas9 system

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Pharmacological brake-release of mRNA translation enhances cognitive memory

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Target identification and mechanism of action in chemical biology and drug discovery

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Phenotypic landscape of a bacterial cell

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Novel trends in high-throughput screening

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Genomic profiling of drug sensitivities via induced haploinsufficiency.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Integrating genetic approaches into the discovery of anticancer drugs

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

Molecular biology. Use and abuse of RNAi to study mammalian gene function

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5507204

15 August 2018

Identifiers

DOI

10.1039/C7CC02349A

1 reference

9 July 2018

PMC publication ID

5507204

1 reference

9 July 2018

PubMed publication ID

28487920

1 reference

9 July 2018