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The Orai1 Store-operated Calcium Channel Functions as a Hexamer.
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5207053
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26 March 2020
title
The Orai1 Store-operated Calcium Channel Functions as a Hexamer
(English)
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26 March 2020
author
Robert M Nwokonko
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3
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26 March 2020
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Xiangyu Cai
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1
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26 March 2020
Yandong Zhou
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2
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26 March 2020
Natalia A Loktionova
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4
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26 March 2020
Xianming Wang
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5
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26 March 2020
Ping Xin
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6
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26 March 2020
Mohamed Trebak
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7
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26 March 2020
Youjun Wang
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8
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26 March 2020
Donald L Gill
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9
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26 March 2020
language of work or name
English
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publication date
25 October 2016
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26 March 2020
published in
Journal of Biological Chemistry
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26 March 2020
volume
291
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26 March 2020
issue
50
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26 March 2020
page(s)
25764-25775
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26 March 2020
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The Orai1 severe combined immune deficiency mutation and calcium release-activated Ca2+ channel function in the heterozygous condition.
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24 May 2018
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
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24 May 2018
Functional stoichiometry of the unitary calcium-release-activated calcium channel
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24 May 2018
Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.
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24 May 2018
Orai1 subunit stoichiometry of the mammalian CRAC channel pore.
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24 May 2018
Orai1 is an essential pore subunit of the CRAC channel
1 reference
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24 May 2018
STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry
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24 May 2018
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
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24 May 2018
Store-Operated Calcium Channels.
1 reference
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retrieved
24 May 2018
The extended transmembrane Orai1 N-terminal (ETON) region combines binding interface and gate for Orai1 activation by STIM1.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5207053
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15 August 2018
The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5207053
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15 August 2018
Signal transduction: STIM1 senses both Ca²+ and heat
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PubMed Central
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retrieved
15 August 2018
Identifiers
DOI
10.1074/JBC.M116.758813
1 reference
stated in
Europe PubMed Central
PMC publication ID
5207053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27780862%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
PMC publication ID
5207053
1 reference
stated in
Europe PubMed Central
PMC publication ID
5207053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27780862%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
PubMed publication ID
27780862
1 reference
stated in
Europe PubMed Central
PMC publication ID
5207053
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27780862%20AND%20SRC:MED&resulttype=core&format=json
retrieved
26 March 2020
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