(Q46363038)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

title

Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference

Shao H Yang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Xin Qiao

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Emily Farber

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

Sandy Y Chang

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

language of work or name

English

0 references

publication date

4 January 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

31 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

volume

283

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

page(s)

7094-7099

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

The nuclear envelope and human disease

31 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Life at the edge: the nuclear envelope and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

"Laminopathies": a wide spectrum of human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Isoprenylation is required for the processing of the lamin A precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Prelamin A and lamin A appear to be dispensable in the nuclear lamina

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Lamin a truncation in Hutchinson-Gilford progeria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

The Hutchinson-Gilford progeria syndrome. Report of 4 cases and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Lamins A and C but not lamin B1 regulate nuclear mechanics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Protein farnesyltransferase inhibitors and progeria

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

Lamin B1 is required for mouse development and nuclear integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708138200

21 January 2018

Identifiers

DOI

10.1074/JBC.M708138200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18178963%20AND%20SRC:MED&resulttype=core&format=json

31 December 2019

1 reference