(Q46384417)

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Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

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9 January 2020

Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model (English)

1 reference

Europe PubMed Central

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9 January 2020

cerebral amyloid angiopathy

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inferred from title

David M. Holtzman

7

object named as

David M Holtzman

2 references

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21 December 2017

Europe PubMed Central

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9 January 2020

author name string

John D Fryer

1

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9 January 2020

Kelly Simmons

2

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9 January 2020

Maia Parsadanian

3

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9 January 2020

Kelly R Bales

4

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9 January 2020

Steven M Paul

5

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9 January 2020

Patrick M Sullivan

6

1 reference

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9 January 2020

language of work or name

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publication date

1 March 2005

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9 January 2020

Journal of Neuroscience

1 reference

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9 January 2020

25

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9 January 2020

2803-2810

1 reference

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9 January 2020

11

1 reference

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9 January 2020

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic overproduction of transforming growth factor-beta1 by astrocytes promotes Alzheimer's disease-like microvascular degeneration in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid β-protein length and cerebral amyloid angiopathy-related haemorrhage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SDS-stable complex formation between native apolipoprotein E3 and beta-amyloid peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular biology of apolipoprotein E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APOE epsilon 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of A beta protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences between vascular and plaque core amyloid in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is Alzheimer's disease an apolipoprotein E amyloidosis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoform-specific binding of apolipoprotein E to beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High frequency of apolipoprotein E ?2 in patients with cerebral hemorrhage due to cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High frequency of apolipoprotein E ?2 Allele in hemorrhage due to cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biology of A beta amyloid in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progression of cerebral amyloid angiopathy: accumulation of amyloid-beta40 in affected vessels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15772340

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5170-04.2005

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15772340%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

release_pwgdh62vbnaunezrn7qh3iur3u

1 reference

https://api.fatcat.wiki/v0/release/pwgdh62vbnaunezrn7qh3iur3u

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15772340%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15772340%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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