(Q46387102)

English

Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

directed evolution

0 references

David J. Waxman

3

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

author name string

Santosh Kumar

1

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

Chong S Chen

2

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

James R Halpert

4

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

language of work or name

0 references

publication date

17 March 2005

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

280

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

20

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

19569-19575

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Directed evolution of industrial enzymes: an update

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Dispelling the myths--biocatalysis in industrial synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Combinatorial and computational challenges for biocatalyst design

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Industrial enzyme applications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Directed evolution of enzymes for applied biocatalysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Engineered enzymes for improved organic synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Generating mutant libraries using error-prone PCR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Preparing libraries in Escherichia coli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Evaluating a screen and analysis of mutant libraries

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500158200

21 January 2018

Identifiers

10.1074/JBC.M500158200

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/15774478

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q46387102&oldid=2109148068"