(Q46429003)

22 December 2017

title

Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat. (English)

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22 December 2017

author name string

Mark R Fielden

1

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22 December 2017

Jonathan Werner

2

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22 December 2017

Jeff A Jamison

3

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22 December 2017

Aldo Coppi

4

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22 December 2017

Dean Hickman

5

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22 December 2017

Robert T Dunn

6

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22 December 2017

Esther Trueblood

7

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22 December 2017

Lei Zhou

8

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22 December 2017

Cynthia A Afshari

9

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22 December 2017

Ruth Lightfoot-Dunn

10

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22 December 2017

language of work or name

English

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publication date

31 October 2014

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22 December 2017

published in

Toxicologic Pathology

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22 December 2017

volume

43

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22 December 2017

issue

4

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22 December 2017

page(s)

581-592

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22 December 2017

A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis

cites work

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Evaluation of different recording parameters to establish a standard for flash electroretinography in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Tracking longitudinal retinal changes in experimental ocular hypertension using the cSLO and spectral domain-OCT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Identification of beta-secretase (BACE1) substrates using quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

BACE1 deficiency causes altered neuronal activity and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

LAMP proteins are required for fusion of lysosomes with phagosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Phagocytosis of retinal rod and cone photoreceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Retinal toxicity associated with hydroxychloroquine and chloroquine: risk factors, screening, and progression despite cessation of therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Fundus autofluorescence findings in a mouse model of retinal detachment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

RPE lipofuscin and its role in retinal pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Cathepsin D deficiency is associated with a human neurodegenerative disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

Correlation between inactive cathepsin D expression and retinal changes in mcd2/mcd2 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314553804

21 January 2018

Identifiers

DOI

10.1177/0192623314553804

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22 December 2017

PubMed ID

25361751

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22 December 2017