(Q36379519)

13 August 2017

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment (English)

1 reference

13 August 2017

16

Antonia M Joussen

1 reference

13 August 2017

12

Maria B Grant

1 reference

13 August 2017

Jun Cai

1

1 reference

13 August 2017

Xiaoping Qi

2

1 reference

13 August 2017

Norbert Kociok

3

1 reference

13 August 2017

Sergej Skosyrski

4

1 reference

13 August 2017

Alonso Emilio

5

1 reference

13 August 2017

Qing Ruan

6

1 reference

13 August 2017

Song Han

7

1 reference

13 August 2017

Li Liu

8

1 reference

13 August 2017

Zhijuan Chen

9

1 reference

13 August 2017

Catherine Bowes Rickman

10

1 reference

13 August 2017

Todd Golde

11

1 reference

13 August 2017

Paul Saftig

13

1 reference

13 August 2017

Lutgarde Serneels

14

1 reference

13 August 2017

Bart de Strooper

15

1 reference

13 August 2017

Michael E Boulton

17

1 reference

13 August 2017

language of work or name

1 reference

20 August 2012

1 reference

13 August 2017

EMBO Molecular Medicine

1 reference

13 August 2017

4

1 reference

13 August 2017

9

1 reference

13 August 2017

980-991

1 reference

describes a project that uses

13 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3491829/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

PEDF regulates vascular permeability by a γ-secretase-mediated pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Retracted: Placenta Growth Factor-1 Exerts Time-Dependent Stabilization of Adherens Junctions Following VEGF-Induced Vascular Permeability

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Secretases as therapeutic targets for Alzheimer's disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

The secretases: enzymes with therapeutic potential in Alzheimer disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Design and synthesis of potent and selective BACE-1 inhibitors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Anti-sphingosine-1-phosphate monoclonal antibodies inhibit angiogenesis and sub-retinal fibrosis in a murine model of laser-induced choroidal neovascularization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

gamma-Secretase: a multifaceted regulator of angiogenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Gamma-secretase regulates VEGFR-1 signalling in vascular endothelium and RPE.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Proliferating endothelial cell-specific expression of IGF-I receptor ribozyme inhibits retinal neovascularization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

The potential role of amyloid beta in the pathogenesis of age-related macular degeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

The neuroprotective and angiogenesis inhibitory serpin, PEDF: new insights into phylogeny, function, and signaling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

RPE lipofuscin and its role in retinal pathobiology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Dual gene therapy with extracellular superoxide dismutase and catalase attenuates experimental optic neuritis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Fluorescence properties of autofluorescent granules generated by cultured human RPE cells.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3491829

Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds

28 June 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201101084

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201101084

Antioxidant up-regulation and increased nuclear DNA protection play key roles in adaptation to oxidative stress in epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201101084

Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201101084

Mitochondrial respiratory inhibition and oxidative stress elevate beta-secretase (BACE1) proteins and activity in vivo in the rat retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201101084

The formation of autofluorescent granules in cultured human RPE

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22903875

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Correlation between autofluorescent debris accumulation and the presence of partially processed forms of cathepsin D in cultured retinal pigment epithelial cells challenged with rod outer segments

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22903875

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/EMMM.201101084

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

22903875

1 reference