(Q46475319)

22 December 2017

title

Measuring cotranslational folding of nascent polypeptide chains on ribosomes (English)

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22 December 2017

Patricia L Clark

1

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author name string

Krastyu G Ugrinov

series ordinal

2

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22 December 2017

language of work or name

English

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publication date

13 November 2009

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22 December 2017

published in

Methods in Enzymology

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22 December 2017

volume

466

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22 December 2017

page(s)

567-590

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22 December 2017

Analysis of the regulatory sequences needed for induction of the chloramphenicol acetyltransferase gene cat-86 by chloramphenicol and amicetin

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Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor

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A newly synthesized, ribosome-bound polypeptide chain adopts conformations dissimilar from early in vitro refolding intermediates.

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Intracellular ribosome display via SecM translation arrest as a selection for antibodies with enhanced cytosolic stability.

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Conserved residues Asp16 and Pro24 of TnaC-tRNAPro participate in tryptophan induction of Tna operon expression

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7 January 2021

In vitro protein folding by ribosomes from Escherichia coli, wheat germ and rat liver: the role of the 50S particle and its 23S rRNA.

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7 January 2021

A segment of mRNA encoding the leader peptide of the CPA1 gene confers repression by arginine on a heterologous yeast gene transcript

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7 January 2021

Functional analysis of the leader peptide of the yeast gene CPA1 and heterologous regulation by other fungal peptides

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7 January 2021

Molecular simulations of cotranslational protein folding: fragment stabilities, folding cooperativity, and trapping in the ribosome

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7 January 2021

Macromolecular crowding: obvious but underappreciated

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Protein aggregation in crowded environments.

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7 January 2021

Chain dynamics of nascent polypeptides emerging from the ribosome

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7 January 2021

Conformations of co-translational folding intermediates

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7 January 2021

Homogeneous stalled ribosome nascent chain complexes produced in vivo or in vitro.

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7 January 2021

Cotranslational folding promotes beta-helix formation and avoids aggregation in vivo

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7 January 2021

A nascent polypeptide domain that can regulate translation elongation

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7 January 2021

Cotranslational protein folding

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7 January 2021

Process of biosynthetic protein folding determines the rapid formation of native structure

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7 January 2021

Truncated staphylococcal nuclease is compact but disordered

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7 January 2021

Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones

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7 January 2021

Co-translational domain folding as the structural basis for the rapid de novo folding of firefly luciferase

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7 January 2021

Three-dimensional structures of translating ribosomes by Cryo-EM.

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7 January 2021

Evidence suggesting cis action by the TnaC leader peptide in regulating transcription attenuation in the tryptophanase operon of Escherichia coli

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7 January 2021

Instruction of translating ribosome by nascent peptide

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7 January 2021

The study of protein folding and dynamics by determination of intramolecular distance distributions and their fluctuations using ensemble and single-molecule FRET measurements

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Pre-binding of small protein B to a stalled ribosome triggers trans-translation

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

In vitro selection and evolution of functional proteins by using ribosome display

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7 January 2021

Co-translational folding

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7 January 2021

Molecular chaperones in the cytosol: from nascent chain to folded protein

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7 January 2021

Converging concepts of protein folding in vitro and in vivo

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7 January 2021

Homologous plant and bacterial proteins chaperone oligomeric protein assembly

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7 January 2021

Trigger factor forms a protective shield for nascent polypeptides at the ribosome.

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7 January 2021

Evolutionary changes in the fungal carbamoyl-phosphate synthetase small subunit gene and its associated upstream open reading frame

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7 January 2021

Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy

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7 January 2021

Structure, dynamics and folding of an immunoglobulin domain of the gelation factor (ABP-120) from Dictyostelium discoideum

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7 January 2021

Modelling sequential protein folding under kinetic control.

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7 January 2021

The structural aspects of limited proteolysis of native proteins

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7 January 2021

Inhibition of translation termination mediated by an interaction of eukaryotic release factor 1 with a nascent peptidyl-tRNA.

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7 January 2021

The co-translational folding and interactions of nascent protein chains: a new approach using fluorescence resonance energy transfer

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7 January 2021

Vectorial transport and folding of an autotransporter virulence protein during outer membrane secretion

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7 January 2021

Fast biosynthesis of GFP molecules: a single-molecule fluorescence study.

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7 January 2021

Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA

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7 January 2021

Cotranslational folding of proteins

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

A pause for thought along the co-translational folding pathway

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

A tRNA-like structure is present in 10Sa RNA, a small stable RNA from Escherichia coli

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Tertiary interactions within the ribosomal exit tunnel

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

The protein folding 'speed limit'.

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7 January 2021

Elongation and folding of nascent ricin chains as peptidyl-tRNA on ribosomes: the effect of amino acid deletions on these processes.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Ribosomes and ribosomal RNA as chaperones for folding of proteins.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Stereochemical analysis of ribosomal transpeptidation. Conformation of nascent peptide

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Nascent peptide regulation of translation

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Folding zones inside the ribosomal exit tunnel

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Secondary structure formation of a transmembrane segment in Kv channels

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Protein translocation through a tunnel induces changes in folding kinetics: a lattice model study.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Partial resistance of nascent polypeptide chains to proteolytic digestion due to ribosomal shielding

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7 January 2021

Nascent chain, mRNA, and ribosome complexes generated by a pure translation system.

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7 January 2021

Molecular mechanism and structure of Trigger Factor bound to the translating ribosome

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7 January 2021

Structure of the E. coli protein-conducting channel bound to a translating ribosome

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7 January 2021

A mammalian sequence-dependent upstream open reading frame mediates polyamine-regulated translation in yeast

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7 January 2021

A comparison of the yeast and rabbit 80 S ribosome reveals the topology of the nascent chain exit tunnel, inter-subunit bridges and mammalian rRNA expansion segments

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Upstream open reading frames as regulators of mRNA translation

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Secretion monitor, SecM, undergoes self-translation arrest in the cytosol

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

The ribosomal exit tunnel functions as a discriminating gate

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Intraribosomal regulation of expression and fate of proteins

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7 January 2021

Acquisition of native-like interactions in C-terminal fragments of barnase

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7 January 2021

Exploring the folding funnel of a polypeptide chain by biophysical studies on protein fragments

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7 January 2021

Co-translational folding of an alphavirus capsid protein in the cytosol of living cells

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7 January 2021

The structural basis of ribosome activity in peptide bond synthesis

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7 January 2021

Efficient protein selection based on ribosome display system with purified components.

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7 January 2021

Identification of a short highly conserved amino acid sequence as the functional region required for posttranscriptional autoregulation of the cystathionine gamma-synthase gene in Arabidopsis

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7 January 2021

Nascent peptide-mediated translation elongation arrest coupled with mRNA degradation in the CGS1 gene of Arabidopsis

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7 January 2021

Nascent peptide-mediated translation elongation arrest of Arabidopsis thaliana CGS1 mRNA occurs autonomously

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7 January 2021

Probing the high energy states in proteins by proteolysis

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7 January 2021

Lattice simulations of cotranslational folding of single domain proteins

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7 January 2021

Fluorescence characterization of the environment encountered by nascent polyalanine and polyserine as they exit Escherichia coli ribosomes during translation.

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7 January 2021

Programmed drug-dependent ribosome stalling

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7 January 2021

Kinetic role of early intermediates in protein folding

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7 January 2021

Ribosome function: governing the fate of a nascent polypeptide

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Dynamics of trigger factor interaction with translating ribosomes

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Large-scale purification of ribosome-nascent chain complexes for biochemical and structural studies.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Revised translation start site for secM defines an atypical signal peptide that regulates Escherichia coli secA expression

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Generation of ribosome nascent chain complexes for structural and functional studies

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Structure of the E. coli signal recognition particle bound to a translating ribosome.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Structures of the bacterial ribosome at 3.5 A resolution

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Chaperone-like activity and surface hydrophobicity of 70S ribosome

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Fluorescence Energy Transfer as a Spectroscopic Ruler

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Ribosome stalling during translation elongation induces cleavage of mRNA being translated in Escherichia coli

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Effective cotranslational folding of firefly luciferase without chaperones of the Hsp70 family

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Ribonuclease H: molecular diversities, substrate binding domains, and catalytic mechanism of the prokaryotic enzymes

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Real-time monitoring of cell-free translation on a quartz-crystal microbalance.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

The green fluorescent protein

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7 January 2021

Single-molecule imaging of full protein synthesis by immobilized ribosomes

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Sequence-specific interactions of nascent Escherichia coli polypeptides with trigger factor and signal recognition particle

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7 January 2021

Quantitative polysome analysis identifies limitations in bacterial cell-free protein synthesis

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

The leader peptide of yeast gene CPA1 is essential for the translational repression of its expression.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

A salvage pathway for protein structures: tmRNA and trans-translation

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Contributions to conformational entropy arising from bond vector fluctuations measured from NMR-derived order parameters: application to protein folding

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Contributions to protein entropy and heat capacity from bond vector motions measured by NMR spin relaxation.

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https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnel

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

Peptide release on the ribosome: mechanism and implications for translational control

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2966024-9

7 January 2021

10.1016/S0076-6879(09)66024-9

Identifiers

DOI

1 reference

22 December 2017

1 reference

22 December 2017