(Q46493878)

22 December 2017

title

Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions (English)

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22 December 2017

author

Sam Hay

1

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22 December 2017

Phillip J. Monaghan

3

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22 December 2017

Rhiannon M Evans

object named as

Rhiannon M Evans

5

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Jiayun Pang

object named as

Jiayun Pang

2

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Nigel Scrutton

8

object named as

Nigel S Scrutton

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22 December 2017

author name string

Xi Wang

4

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22 December 2017

Michael J Sutcliffe

6

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22 December 2017

Rudolf K Allemann

7

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22 December 2017

publication date

1 August 2008

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22 December 2017

published in

ChemPhysChem

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22 December 2017

volume

9

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22 December 2017

issue

11

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22 December 2017

page(s)

1536-1539

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22 December 2017

A perspective on enzyme catalysis.

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Biochemistry. Enzyme motions inside and out.

1 reference

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Enzymes: By chance, or by design?

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The dynamic energy landscape of dihydrofolate reductase catalysis

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How enzymes work: analysis by modern rate theory and computer simulations

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Hydrogen tunneling in enzyme reactions

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7 January 2021

Atomic description of an enzyme reaction dominated by proton tunneling

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7 January 2021

α-Secondary Isotope Effects as Probes of “Tunneling-Ready” Configurations in Enzymatic H-Tunneling: Insight from Environmentally Coupled Tunneling Models

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Promoting motions in enzyme catalysis probed by pressure studies of kinetic isotope effects

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Transition state theory can be used in studies of enzyme catalysis: lessons from simulations of tunnelling and dynamical effects in lipoxygenase and other systems

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7 January 2021

The role of tunneling in enzyme catalysis of C-H activation

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7 January 2021

Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quinoprotein systems.

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7 January 2021

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase

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7 January 2021

Protein motions during catalysis by dihydrofolate reductases.

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7 January 2021

Hydride transfer catalysed by Escherichia coli and Bacillus subtilis dihydrofolate reductase: coupled motions and distal mutations

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7 January 2021

Coupling of hydrogenic tunneling to active-site motion in the hydrogen radical transfer catalyzed by a coenzyme B12-dependent mutase

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7 January 2021

Enzymatic H-transfer requires vibration-driven extreme tunneling

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7 January 2021

Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase.

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Alpha-secondary tritium kinetic isotope effects indicate hydrogen tunneling and coupled motion occur in the oxidation of L-malate by NAD-malic enzyme

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Boundary conditions for the Swain-Schaad relationship as a criterion for hydrogen tunneling

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

The normal range for secondary Swain-Schaad exponents without tunneling or kinetic complexity

1 reference

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7 January 2021

H-tunneling in the multiple H-transfers of the catalytic cycle of morphinone reductase and in the reductive half-reaction of the homologous pentaerythritol tetranitrate reductase.

1 reference

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7 January 2021

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis

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7 January 2021

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

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https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Steady-state analysis of kinetic isotope effects in enzymic reactions

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Hydride transfer reaction catalyzed by hyperthermophilic dihydrofolate reductase is dominated by quantum mechanical tunneling and is promoted by both inter- and intramonomeric correlated motions.

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation.

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Reaction-path energetics and kinetics of the hydride transfer reaction catalyzed by dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima

1 reference

https://api.crossref.org/works/10.1002%2FCPHC.200800291

7 January 2021

Identifiers

DOI

10.1002/CPHC.200800291

1 reference

22 December 2017

1 reference

22 December 2017