(Q46500452)

22 December 2017

title

The talinolol double-peak phenomenon is likely caused by presystemic processing after uptake from gut lumen (English)

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22 December 2017

author

Werner Weitschies

1

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22 December 2017

author name string

Annika Bernsdorf

2

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22 December 2017

Thomas Giessmann

3

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22 December 2017

Michael Zschiesche

4

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22 December 2017

Christiane Modess

5

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22 December 2017

Vera Hartmann

6

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22 December 2017

Claudia Mrazek

7

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22 December 2017

Danilo Wegner

8

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22 December 2017

Stefan Nagel

9

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22 December 2017

Werner Siegmund

10

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22 December 2017

publication date

17 May 2005

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22 December 2017

published in

Pharmaceutical Research

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22 December 2017

volume

22

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22 December 2017

issue

5

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22 December 2017

page(s)

728-735

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22 December 2017

Paracetamol absorption from different sites in the human small intestine

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Relevance of p-glycoprotein for the enteral absorption of cyclosporin A: in vitro-in vivo correlation

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Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat

21 January 2018

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Pharmacokinetics of halofantrine in man: effects of food and dose size

21 January 2018

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Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

21 January 2018

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12 December 2020

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Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells

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Enterohepatic circulation: physiological, pharmacokinetic and clinical implications

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12 December 2020

Pharmacokinetic strategies in deciphering atypical drug absorption profiles

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12 December 2020

P-glycoprotein increases from proximal to distal regions of human small intestine

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12 December 2020

Transport and metabolism of vitamin A.

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12 December 2020

Unexpected effect of verapamil on oral bioavailability of the beta-blocker talinolol in humans

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12 December 2020

Region-dependent modulation of intestinal permeability by drug efflux transporters: in vitro studies in mdr1a(-/-) mouse intestine

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12 December 2020

Stereoselective interactions of organic cations with the organic cation transporter in OK cells

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12 December 2020

Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil

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12 December 2020

KINETIC STUDIES ON THE DEVELOPMENT OF LIPID RESORPTION IN RELATION WITH THE LYMPH FLOW RATE

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12 December 2020

Oral bioavailability of digoxin is enhanced by talinolol: evidence for involvement of intestinal P-glycoprotein

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12 December 2020

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

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Absorption of danazol after administration to different sites of the gastrointestinal tract and the relationship to single- and double-peak phenomena in the plasma profiles

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12 December 2020

Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine; comparison to the liver

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12 December 2020

Stereoselective disposition of talinolol in man.

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12 December 2020

A double-peak phenomenon in the pharmacokinetics of veralipride after oral administration: a double-site model for drug absorption

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12 December 2020

The influence of variable gastric emptying and intestinal transit rates on the plasma level curve of cimetidine; an explanation for the double peak phenomenon.

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12 December 2020

Intestinal lymphatic drug transport: an update

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12 December 2020

The role of lymphatic transport in enhancing oral protein and peptide drug delivery

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12 December 2020

Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease?

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12 December 2020

Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds

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12 December 2020

Mobilisation of enterocyte fat stores by oral glucose in humans.

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12 December 2020

Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.

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12 December 2020

Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).

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12 December 2020

Evidence for an interaction between the beta-blocker pafenolol and bile salts in the intestinal lumen of the rat leading to dose-dependent oral absorption and double peaks in the plasma concentration-time profile

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12 December 2020

Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo.

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12 December 2020

Mechanisms involved in the intestinal digestion and absorption of dietary vitamin A

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12 December 2020

In vivo evaluation of enteric-coated naproxen tablets using gamma scintigraphy

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12 December 2020

The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers

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12 December 2020

Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction

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12 December 2020

Effect of levothyroxine administration on intestinal P-glycoprotein expression: consequences for drug disposition.

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12 December 2020

Disposition and bioavailability of the beta 1-adrenoceptor antagonist talinolol in man.

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12 December 2020

Site-dependent small intestinal absorption of ranitidine

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12 December 2020

P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans

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12 December 2020

Influence of cimetidine co-administration on the pharmacokinetics of acebutolol enantiomers and its metabolite diacetolol in a rat model: the effect of gastric pH on double-peak phenomena

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12 December 2020

The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

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12 December 2020

Celiprolol double-peak occurrence and gastric motility: nonlinear mixed effects modeling of bioavailability data obtained in dogs

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12 December 2020

Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations

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12 December 2020

Vitamin A uptake from foods

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12 December 2020

Mechanism of intestinal absorption of ranitidine and ondansetron: transport across Caco-2 cell monolayers

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12 December 2020

Gastric emptying: comparison of scintigraphic, polyethylene glycol dilution, and paracetamol tracer assessment techniques

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12 December 2020

Polyspecific organic cation transporters: their functions and interactions with drugs

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12 December 2020

The biliary elimination of the selective beta-receptor blocking drug talinolol in man.

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12 December 2020

Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics

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12 December 2020

Gastrointestinal drug absorption: is it time to consider heterogeneity as well as homogeneity?

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12 December 2020

Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans

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12 December 2020

10.1007/S11095-005-2588-5

Identifiers

DOI

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22 December 2017

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22 December 2017