(Q46534639)

22 December 2017

title

Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice (English)

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22 December 2017

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X D Wang

1

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22 December 2017

M Z Vatamaniuk

2

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22 December 2017

S K Wang

3

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22 December 2017

C A Roneker

4

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22 December 2017

R A Simmons

5

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22 December 2017

X G Lei

6

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22 December 2017

publication date

17 June 2008

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22 December 2017

published in

Diabetologia

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22 December 2017

volume

51

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22 December 2017

issue

8

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22 December 2017

page(s)

1515-1524

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22 December 2017

https://scigraph.springernature.com/pub.10.1007/s00125-008-1055-3

exact match

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cites work

Overexpression of cellular glutathione peroxidase does not affect expression of plasma glutathione peroxidase or phospholipid hydroperoxide glutathione peroxidase in mice offered diets adequate or deficient in selenium

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12 December 2020

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

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12 December 2020

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

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12 December 2020

Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics.

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12 December 2020

Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function

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12 December 2020

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

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12 December 2020

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

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12 December 2020

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

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12 December 2020

Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation

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12 December 2020

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

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12 December 2020

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

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12 December 2020

Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression

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12 December 2020

Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy

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12 December 2020

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

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12 December 2020

Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells

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12 December 2020

Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms

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12 December 2020

Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets

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12 December 2020

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

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12 December 2020

Metallothionein and catalase sensitize to diabetes in nonobese diabetic mice: reactive oxygen species may have a protective role in pancreatic beta-cells

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12 December 2020

The neuroprotective efficacy of ebselen (a glutathione peroxidase mimic) on brain damage induced by transient focal cerebral ischaemia in the rat

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12 December 2020

A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation

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12 December 2020

A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

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12 December 2020

Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes

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12 December 2020

Role of oxidative stress in pancreatic beta-cell dysfunction

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12 December 2020

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

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12 December 2020

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

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12 December 2020

Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes

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12 December 2020

Conserved transcriptional regulatory domains of the pdx-1 gene

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12 December 2020

The insulin gene promoter. A simplified nomenclature.

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12 December 2020

Dissociation of the obesity-hyperinsulinism relationship following dietary restriction and hyperalimentation

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12 December 2020

Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway

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12 December 2020

Alternative chromatin structure at CpG islands

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12 December 2020

The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation

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12 December 2020

Nucleosome linking number change controlled by acetylation of histones H3 and H4.

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12 December 2020

Mechanisms of compensatory beta-cell growth in insulin-resistant rats: roles of Akt kinase.

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12 December 2020

Reactive oxygen species as a signal in glucose-stimulated insulin secretion

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12 December 2020

Pancreatic islet expression of the homeobox factor STF-1 relies on an E-box motif that binds USF.

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12 December 2020

Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

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12 December 2020

MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity

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12 December 2020

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

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12 December 2020

An improved method for isolation of mouse pancreatic islets

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12 December 2020

CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse.

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12 December 2020

Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice

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12 December 2020

Controlling caloric consumption: protocols for rodents and rhesus monkeys

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12 December 2020

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

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12 December 2020

Protection of insulin-secreting INS-1 cells against oxidative stress through adenoviral-mediated glutathione peroxidase overexpression

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12 December 2020

Overexpression of extracellular-SOD in islets of nonobese diabetic mice and development of diabetes

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12 December 2020

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

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12 December 2020

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

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12 December 2020

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

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12 December 2020

10.1007/S00125-008-1055-3

Identifiers

DOI

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22 December 2017

PubMed ID

18560803

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22 December 2017