(Q46595840)

23 December 2017

title

Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states (English)

1 reference

23 December 2017

author name string

Satoko Osawa

1

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23 December 2017

Satoru Funamoto

2

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23 December 2017

Mika Nobuhara

3

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23 December 2017

Satoko Wada-Kakuda

4

1 reference

23 December 2017

Masafumi Shimojo

5

1 reference

23 December 2017

Sosuke Yagishita

6

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23 December 2017

Yasuo Ihara

7

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23 December 2017

language of work or name

English

0 references

publication date

14 May 2008

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23 December 2017

Journal of Biological Chemistry

published in

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23 December 2017

volume

283

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23 December 2017

issue

28

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23 December 2017

page(s)

19283-19292

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23 December 2017

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

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Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

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The role of presenilin cofactors in the gamma-secretase complex

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

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Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

21 January 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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Purification and characterization of the human gamma-secretase complex

21 January 2018

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Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

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Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism

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21 January 2018

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Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling

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Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids

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Phosphatidylinositol-4,5-bisphosphate regulates NMDA receptor activity through alpha-actinin.

21 January 2018

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Comparison of the levels of inositol metabolites in transformed haemopoietic cells and their normal counterparts.

21 January 2018

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Signal-dependent membrane targeting by pleckstrin homology (PH) domains

21 January 2018

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Cell control by membrane-cytoskeleton adhesion

21 January 2018

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GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Spatial segregation of gamma-secretase and substrates in distinct membrane domains

21 January 2018

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Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

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Gamma-secretase activity is present in rafts but is not cholesterol-dependent

21 January 2018

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Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

21 January 2018

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Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils

21 January 2018

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Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

21 January 2018

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Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products

21 January 2018

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Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels.

21 January 2018

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Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

21 January 2018

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Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.

21 January 2018

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Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.

21 January 2018

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Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1

21 January 2018

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Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

21 January 2018

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Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

21 January 2018

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Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein

21 January 2018

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Triphosphoinositide increases glycoprotein lateral mobility in erythrocyte membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705954200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705954200

1 reference

23 December 2017

1 reference

23 December 2017