(Q40478080)

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Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 September 2017

Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity. (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

1 reference

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Jonathan D J Wrigley

1

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Irina Schurov

2

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Emma J Nunn

3

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Agnes C L Martin

4

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Earl E Clarke

5

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Semantha Ellis

6

1 reference

Europe PubMed Central

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20 September 2017

Timothy P Bonnert

7

1 reference

Europe PubMed Central

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20 September 2017

Mark S Shearman

8

1 reference

Europe PubMed Central

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20 September 2017

Dirk Beher

9

1 reference

Europe PubMed Central

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20 September 2017

language of work or name

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publication date

21 December 2004

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Europe PubMed Central

PubMed publication ID

20 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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20 September 2017

280

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

13

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

12523-12535

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

A familial Alzheimer's disease locus on chromosome 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Gamma-secretase activity is associated with a conformational change of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Generation of beta A4 from the amyloid protein precursor and fragments thereof

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Gamma-secretase activity is present in rafts but is not cholesterol-dependent

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Gamma-secretase activity is not involved in presenilin-mediated regulation of beta-catenin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Presenilin-dependent gamma-secretase activity modulates thymocyte development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Purification and characterization of the human gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Cholesterol and the biology of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M413086200

21 January 2018

Identifiers

10.1074/JBC.M413086200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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