(Q46607400)

English

Damage-induced activation of ERK1/2 in cochlear supporting cells is a hair cell death-promoting signal that depends on extracellular ATP and calcium.

scientific article published in May 2008

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scholarly article

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Damage-induced activation of ERK1/2 in cochlear supporting cells is a hair cell death-promoting signal that depends on extracellular ATP and calcium (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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based on heuristic

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Jonathan E Gale

2

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

author name string

Manuela Lahne

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

language of work or name

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publication date

1 May 2008

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

number of pages

11

1 reference

based on heuristic

inferred from page(s)

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

28

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

19

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

4918-4928

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the P2X(2) receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptotic death of hair cells in mammalian vestibular sensory epithelia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminoglycoside antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The discovery of potent cRaf1 kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol-3 kinase, mammalian target of rapamycin, and S6 kinases in preference to calcium, protein kinase C, and mitogen-activated [...]

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propagation of intercellular calcium waves in retinal astrocytes and Müller cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vesicular storage of adenosine triphosphate in the guinea-pig cochlear lateral wall and concentrations of ATP in the endolymph during sound exposure and hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of p42/44(MAPK) by various signal transduction pathways activates cytosolic phospholipase A(2) to variable degrees

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's saccule

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The extracellular regulated kinases (ERK) 1/2 mediate cannabinoid-induced inhibition of gap junctional communication in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the mitogen activated protein kinase extracellular signal-regulated kinase 1 and 2 by the nitric oxide-cGMP-cGMP-dependent protein kinase axis regulates the expression of matrix metalloproteinase 13 in vascular endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics of noise-induced cellular injury and repair in the mouse cochlea

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK and SAPK signaling in auditory brainstem neurons after unilateral cochlear ablation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of ras activation in toxic hair cell damage of the mammalian cochlea

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of activator protein 1/DNA binding activity by acoustic overstimulation in the guinea-pig cochlea

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular injury induces activation of MAPK via P2Y receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanism for sensing noise damage in the inner ear.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAP kinases and cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical signaling events during the aminoglycoside-induced death of sensory hair cells in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fundamental role of nitric oxide in neuritogenesis of PC12h cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective permeability of different connexin channels to the second messenger cyclic AMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of apoptosis by P2Y2 receptor activation: novel pathways for neuronal survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemia opens neuronal gap junction hemichannels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fate of outer hair cells after acoustic or ototoxic insults

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purinergic signalling and intercellular Ca2+ wave propagation in the organ of Corti

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scar formation after drug-induced cochlear insult

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Shape change controls supporting cell proliferation in lesioned mammalian balance epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Large scale gene expression profiles of regenerating inner ear sensory epithelia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Closure of supporting cell scar formations requires dynamic actin mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cochlear cultures as a model system for studying aminoglycoside induced ototoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dye coupling in the organ of Corti.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gap junctions in the rat cochlea: immunohistochemical and ultrastructural analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regeneration and mammalian auditory hair cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of growth factor receptors in the mammalian UVC response

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transformation of mammalian cells by constitutively active MAP kinase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cPLA2 is phosphorylated and activated by MAP kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cell motility by mitogen-activated protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ERK and p38 MAP kinase pathways are mediators of intestinal epithelial wound-induced signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoform composition of connexin channels determines selectivity among second messengers and uncharged molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preconditioning with bright light evokes a protective response against light damage in the rat retina.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel inhibitor of mitogen-activated protein kinase kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18463245

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4914-07.2008

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18463245%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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