(Q46614261)

English

The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells

scientific article published on 29 January 2013

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scholarly article

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells (English)

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

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ChEBI release 2020-05-28

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author name string

Elisabeth J Walsby

1

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

Michelle Lazenby

2

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

Chris J Pepper

3

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

Steven Knapper

4

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

Alan K Burnett

5

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

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publication date

29 January 2013

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

British Journal of Haematology

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

161

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

1

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Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

57-67

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

Targeting cell signaling pathways for drug discovery: an old lock needs a new key.

1 reference

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21 January 2018

Heat shock protein 90 as a drug target: some like it hot.

1 reference

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21 January 2018

The Clinical Applications of Heat Shock Protein Inhibitors in Cancer - Present and Future

1 reference

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Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

1 reference

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Heat shock protein 90 inhibitor BIIB021 (CNF2024) depletes NF-kappaB and sensitizes Hodgkin's lymphoma cells for natural killer cell-mediated cytotoxicity

1 reference

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Development of Purine-Scaffold Small Molecule Inhibitors of Hsp90

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Drug combination studies and their synergy quantification using the Chou-Talalay method

1 reference

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21 January 2018

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

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STI571 (Gleevec) as a paradigm for cancer therapy

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

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Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells

1 reference

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21 January 2018

Significance of heat-shock protein (HSP) 90 expression in acute myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1111%2FBJH.12215

21 January 2018

PI3K: downstream AKTion blocks apoptosis

1 reference

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21 January 2018

Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3.

1 reference

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21 January 2018

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

1 reference

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21 January 2018

Molecular genetics of human leukemias: new insights into therapy

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21 January 2018

17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

1 reference

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21 January 2018

Targeting heat shock proteins in cancer

1 reference

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21 January 2018

Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia

1 reference

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21 January 2018

BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

1 reference

https://api.crossref.org/works/10.1111%2FBJH.12215

21 January 2018

Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine

1 reference

https://api.crossref.org/works/10.1111%2FBJH.12215

21 January 2018

Molecular chaperones and the stress of oncogenesis.

1 reference

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21 January 2018

Hsp90 inhibitors as novel cancer chemotherapeutic agents

1 reference

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21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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21 January 2018

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

1 reference

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21 January 2018

Heat shock protein 90 - a potential target in the treatment of human acute myelogenous leukemia

1 reference

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21 January 2018

Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention.

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21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

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21 January 2018

Modulation of Akt kinase activity by binding to Hsp90

1 reference

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21 January 2018

Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating

1 reference

https://api.crossref.org/works/10.1111%2FBJH.12215

21 January 2018

Development and application of Hsp90 inhibitors

1 reference

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21 January 2018

Targeting Hsp90: small-molecule inhibitors and their clinical development

1 reference

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21 January 2018

All-trans-retinoic acid in acute promyelocytic leukemia

1 reference

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21 January 2018

Natural Product Origins of Hsp90 Inhibitors

1 reference

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21 January 2018

17 AAG for HSP90 inhibition in cancer--from bench to bedside

1 reference

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21 January 2018

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-κB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells

1 reference

https://api.crossref.org/works/10.1111%2FBJH.12215

21 January 2018

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

1 reference

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21 January 2018

The Stress Response: Implications for the Clinical Development of Hsp90 Inhibitors

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Overview: Translating Hsp90 Biology into Hsp90 Drugs

1 reference

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Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51.

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21 January 2018

More than folding: localized functions of cytosolic chaperones

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21 January 2018

High constitutive expression of heat shock protein 90α in human acute leukemia cells

1 reference

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21 January 2018

Identifiers

10.1111/BJH.12215

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

1 reference

Europe PubMed Central

23 December 2017

http://europepmc.org/abstract/MED/23356405

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