(Q46616830)

English

Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations

scientific article published on 28 March 2012

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scholarly article

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

Alzheimer's disease

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Srinivasan Ramachandran

object named as

Srinivasan Ramachandran

4

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Fernando Teran Arce

object named as

Fernando Teran Arce

3

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6

object named as

Ruth Nussinov

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

2

object named as

Hyunbum Jang

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

5

object named as

Bruce L Kagan

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

7

object named as

Ratnesh Lal

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

Laura Connelly-Smith

1

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Laura Connelly

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

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publication date

28 March 2012

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

51

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Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

14

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

3031-3038

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

The pore dimensions of gramicidin A.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Architecture of the Alzheimer's A beta P ion channel pore

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scanning cysteine mutagenesis analysis of Abeta-(1-40) amyloid fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein misfolding, functional amyloid, and human disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid ion channels: a common structural link for protein-misfolding disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folding proteins in fatal ways

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolines and amyloidogenicity in fragments of the Alzheimer's peptide beta/A4

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Theoretical models of the ion channel structure of amyloid beta-protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

β-Barrel topology of Alzheimer's β-amyloid ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein: monomer structure and early aggregation states of Abeta42 and its Pro19 alloform.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenesis of the central hydrophobic cluster in Abeta42 Alzheimer's peptide. Side-chain properties correlate with aggregation propensities

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic protein-membrane interactions: mechanistic insight from model systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Scalable molecular dynamics with NAMD

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review: history of the amyloid fibril

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural classification of toxic amyloid oligomers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid beta ion channel hypothesis of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The toxicity in vitro of beta-amyloid protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein folding and misfolding

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic analysis of beta-amyloid fibril elongation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monitoring the assembly of Ig light-chain amyloid fibrils by atomic force microscopy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural convergence among diverse, toxic beta-sheet ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New structures help the modeling of toxic amyloidbeta ion channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurodegenerative disease: amyloid pores from pathogenic mutations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22413858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI300257E

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 December 2017

http://europepmc.org/abstract/MED/22413858

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