(Q46618468)

23 December 2017

title

Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo (English)

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23 December 2017

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Jeffery D Molkentin

8

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author name string

Robert A Kaiser

1

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23 December 2017

Qiangrong Liang

2

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23 December 2017

Orlando Bueno

3

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23 December 2017

Yuan Huang

4

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23 December 2017

Troy Lackey

5

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23 December 2017

Raisa Klevitsky

6

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23 December 2017

Timothy E Hewett

7

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23 December 2017

language of work or name

English

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publication date

25 July 2005

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23 December 2017

Journal of Biological Chemistry

published in

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23 December 2017

volume

280

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23 December 2017

issue

38

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23 December 2017

page(s)

32602-32608

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23 December 2017

Organization and regulation of mitogen-activated protein kinase signaling pathways

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Signal transduction by the JNK group of MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

The JNK signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Convergence of MAP kinase pathways on the ternary complex factor Sap-1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation. HSP72 alleviates the stewss-induced inhibition of JNK dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Cytoprotection by Jun kinase during nitric oxide-induced cardiac myocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Activation of c-Jun N-terminal kinase promotes survival of cardiac myocytes after oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Transgenic remodeling of the regulatory myosin light chains in the mammalian heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Analyzing JNK and p38 mitogen-activated protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

STRESS signaling pathways that modulate cardiac myocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500684200

21 January 2018

Identifiers

DOI

10.1074/JBC.M500684200

1 reference

23 December 2017

release_y2bvy3w3lrafplh5tiqy76kt44

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/y2bvy3w3lrafplh5tiqy76kt44

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

23 December 2017