(Q46669000)

24 December 2017

title

The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties (English)

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24 December 2017

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5

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24 December 2017

Nobutaka Hattori

7

object named as

Nobutaka Hattori

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24 December 2017

Shin-Ei Matsumoto

1

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24 December 2017

Yumiko Motoi

2

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24 December 2017

Koichi Ishiguro

3

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24 December 2017

Takeshi Tabira

4

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24 December 2017

Masato Hasegawa

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24 December 2017

publication date

15 September 2015

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24 December 2017

published in

Human Molecular Genetics

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24 December 2017

volume

24

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24 December 2017

page(s)

6403-6416

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24 December 2017

issue

22

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24 December 2017

Neurodegenerative tauopathies

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Post-translational modifications of tau protein: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Tau alteration and neuronal degeneration in tauopathies: mechanisms and models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Generation of tau aggregates and clearance by autophagy in an inducible cell model of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Tau, tangles, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Truncation of tau at E391 promotes early pathologic changes in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Hyperphosphorylation and cleavage at D421 enhance tau secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Neuropathological stageing of Alzheimer-related changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Transmission and spreading of tauopathy in transgenic mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Propagation of tau misfolding from the outside to the inside of a cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Constitutive secretion of tau protein by an unconventional mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Neuronal activity regulates extracellular tau in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Physiological release of endogenous tau is stimulated by neuronal activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Starvation and inhibition of lysosomal function increased tau secretion by primary cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Neuronal and glial calcium signaling in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

The C-terminus of tau protein plays an important role in its stability and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

The acetylation of tau inhibits its function and promotes pathological tau aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Differential regulation of dynein and kinesin motor proteins by tau

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Calpain in the CNS: from synaptic function to neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Oligodendrocyte progenitor cells proliferate and survive in an immature state following treatment with an axolemma-enriched fraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Calpain cleavage prediction using multiple kernel learning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Complementary dimerization of microtubule-associated tau protein: Implications for microtubule bundling and tau-mediated pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Prion-like properties of pathological TDP-43 aggregates from diseased brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV351

21 January 2018

Identifiers

DOI

10.1093/HMG/DDV351

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24 December 2017

PubMed ID

26374846

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24 December 2017