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Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease
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scholarly article
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stated in
PubMed
title
Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease
(English)
1 reference
stated in
PubMed
main subject
pathogenesis
1 reference
based on heuristic
inferred from title
Alzheimer's disease
1 reference
based on heuristic
inferred from title
author name string
Adrianne S. Chesser
series ordinal
1
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stated in
Crossref
Susanne M. Pritchard
series ordinal
2
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stated in
Crossref
Gail V. W. Johnson
series ordinal
3
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
3 September 2013
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stated in
PubMed
published in
Frontiers in Neurology
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stated in
Crossref
volume
4
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stated in
PubMed
page(s)
122
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stated in
PubMed
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The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine
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Tau oligomers and tau toxicity in neurodegenerative disease
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Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP.
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Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease
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Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
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Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356.
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Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation
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The acetylation of tau inhibits its function and promotes pathological tau aggregation
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28 September 2017
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A caspase cleaved form of tau is preferentially degraded through the autophagy pathway
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28 September 2017
Proteasome-caspase-cathepsin sequence leading to tau pathology induced by prostaglandin J2 in neuronal cells
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Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening
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Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease
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Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression
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Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model
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Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro
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28 September 2017
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28 September 2017
Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease
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Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells
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Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease?
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31 May 2018
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
31 May 2018
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
31 May 2018
Lysosomal protease inhibitors induce meganeurites and tangle-like structures in entorhinohippocampal regions vulnerable to Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
31 May 2018
Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
31 May 2018
Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
31 May 2018
Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
31 May 2018
Cytosolic proteolysis of tau by cathepsin D in hippocampus following suppression of cathepsins B and L.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
31 May 2018
Proteolysis of microtubule-associated protein 2 and tubulin by cathepsin D.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
31 May 2018
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
NDP52: the missing link between ubiquitinated bacteria and autophagy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Proteolysis of non-phosphorylated and phosphorylated tau by thrombin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Microtubule-associated protein tau is a substrate of ATP/Mg(2+)-dependent proteasome protease system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Proteasomal degradation of tau protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Calcineurin inhibition prevents calpain-mediated proteolysis of tau in differentiated PC12 cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Proteolytic degradation of microtubule associated protein tau by thrombin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759803
retrieved
28 November 2018
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24027553
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Impaired proteasome function in Alzheimer's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24027553
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chaperone-Mediated Autophagy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24027553
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Specific processing of native and phosphorylated tau protein by proteases
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24027553
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Thrombin perturbs neurite outgrowth and induces apoptotic cell death in enriched chick spinal motoneuron cultures through caspase activation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24027553
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3389/FNEUR.2013.00122
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
954371
OpenCitations bibliographic resource ID
954371
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
954371
PMCID
3759803
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
954371
PubMed ID
24027553
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
954371
ResearchGate publication ID
256502236
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