(Q37843432)

24 August 2017

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title

HTRA proteases: regulated proteolysis in protein quality control (English)

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24 August 2017

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1

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24 August 2017

Michael Ehrmann

4

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Robert Huber

series ordinal

3

object named as

Robert Huber

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24 August 2017

Markus Kaiser

2

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24 August 2017

16 February 2011

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Nature Reviews Molecular Cell Biology

24 August 2017

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24 August 2017

12

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24 August 2017

152-162

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24 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nrm3065

24 August 2017

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cites work

Evolution of peptidase diversity

1 reference

The HtrA Family of Proteases

31 March 2020

1 reference

Structural basis for the regulated protease and chaperone function of DegP

31 March 2020

1 reference

Deg/HtrA proteases as components of a network for photosystem II quality control in chloroplasts and cyanobacteria

31 March 2020

1 reference

Serine protease HtrA1 associates with microtubules and inhibits cell migration

31 March 2020

1 reference

Emerging roles of serine proteinases in tissue turnover in arthritis

31 March 2020

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HtrA serine proteases as potential therapeutic targets in cancer

31 March 2020

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Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease.

31 March 2020

1 reference

Age-related macular degeneration

31 March 2020

1 reference

The mitochondrial serine protease HtrA2/Omi: an overview

31 March 2020

1 reference

Implications of the serine protease HtrA1 in amyloid precursor protein processing

31 March 2020

1 reference

Protease gene families in Populus and Arabidopsis

31 March 2020

1 reference

The thylakoid lumen protease Deg1 is involved in the repair of photosystem II from photoinhibition in Arabidopsis

31 March 2020

1 reference

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

31 March 2020

1 reference

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

31 March 2020

1 reference

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins

31 March 2020

1 reference

Expression and characterization of a serine protease that preferentially cleaves insulin-like growth factor binding protein-5.

31 March 2020

1 reference

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

31 March 2020

1 reference

Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins.

31 March 2020

1 reference

Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control

31 March 2020

1 reference

The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP.

31 March 2020

1 reference

Biochemical characterization and mass spectrometric disulfide bond mapping of periplasmic alpha-amylase MalS of Escherichia coli.

31 March 2020

1 reference

Role of the PDZ domains in Escherichia coli DegP protein

31 March 2020

1 reference

The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress

31 March 2020

1 reference

The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 degrees C.

31 March 2020

1 reference

The thylakoid protease Deg1 is involved in photosystem-II assembly in Arabidopsis thaliana

31 March 2020

1 reference

Design principles of the proteolytic cascade governing the sigmaE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction.

31 March 2020

1 reference

OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain

31 March 2020

1 reference

The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation

31 March 2020

1 reference

Bacterial proteases from the intracellular vacuole niche; protease conservation and adaptation for pathogenic advantage

31 March 2020

1 reference

Proteases in bacterial pathogenesis

31 March 2020

1 reference

Role of DegP for two-partner secretion in Bordetella

31 March 2020

1 reference

Role of HtrA in surface protein expression and biofilm formation by Streptococcus mutans

31 March 2020

1 reference

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

31 March 2020

1 reference

Identification and characterization of DegP, a serine protease associated with the luminal side of the thylakoid membrane.

31 March 2020

1 reference

The stromal chloroplast Deg7 protease participates in the repair of photosystem II after photoinhibition in Arabidopsis

31 March 2020

1 reference

Formation of DEG5 and DEG8 complexes and their involvement in the degradation of photodamaged photosystem II reaction center D1 protein in Arabidopsis.

31 March 2020

1 reference

Primary structure of a putative serine protease specific for IGF-binding proteins

31 March 2020

1 reference

Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

31 March 2020

1 reference

The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells

31 March 2020

1 reference

HtrA1-dependent proteolysis of TGF-beta controls both neuronal maturation and developmental survival.

31 March 2020

1 reference

The serine protease HtrA1 specifically interacts and degrades the tuberous sclerosis complex 2 protein

31 March 2020

1 reference

The role of human HtrA1 in arthritic disease

31 March 2020

1 reference

Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis

31 March 2020

1 reference

Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia

31 March 2020

1 reference

Mitochondrial dysfunction in Parkinson's disease

31 March 2020

1 reference

HAX-1: a multifunctional protein with emerging roles in human disease

31 March 2020

1 reference

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

31 March 2020

1 reference

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

31 March 2020

1 reference

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.

31 March 2020

1 reference

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

31 March 2020

1 reference

HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.

31 March 2020

1 reference

Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria.

31 March 2020

1 reference

Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling

31 March 2020

1 reference

Identification of novel endometrial targets for contraception

31 March 2020

1 reference

High-temperature requirement factor A3 (Htra3): a novel serine protease and its potential role in ovarian function and ovarian cancers

31 March 2020

1 reference

Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer

31 March 2020

1 reference

Methylation induced gene silencing of HtrA3 in smoking-related lung cancer

31 March 2020

1 reference

High temperature requirement A3 (HtrA3) promotes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines

31 March 2020

1 reference

PDZ domains and the organization of supramolecular complexes

31 March 2020

1 reference

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease.

31 March 2020

1 reference

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

31 March 2020

1 reference

Substrate-induced remodeling of the active site regulates human HTRA1 activity

31 March 2020

1 reference

Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ

31 March 2020

1 reference

Evolutionary expansion and specialization of the PDZ domains

31 March 2020

1 reference

Human beta-tryptase is a ring-like tetramer with active sites facing a central pore

31 March 2020

1 reference

Structural basis of the activation and action of trypsin

31 March 2020

1 reference

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

31 March 2020

1 reference

Induction of the bovine trypsinogen-trypsin transition by peptides sequentially similar to the N-terminus of trypsin

31 March 2020

1 reference

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. The refined crystal structures of the bovine trypsinogen-pancreatic trypsin inhibitor complex and of its ternary complex with Ile-Val at 1.9 A resolution

31 March 2020

1 reference

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

31 March 2020

1 reference

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation.

31 March 2020

1 reference

Conversion of a regulatory into a degradative protease

31 March 2020

1 reference

Determinants of structural and functional plasticity of a widely conserved protease chaperone complex

31 March 2020

1 reference

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

31 March 2020

1 reference

Regulation of the E stress response by DegS: how the PDZ domain keeps the protease inactive in the resting state and allows integration of different OMP-derived stress signals upon folding stress

31 March 2020

1 reference

OMP Peptides Activate the DegS Stress-Sensor Protease by a Relief of Inhibition Mechanism

31 March 2020

1 reference

Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine

31 March 2020

1 reference

Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control

31 March 2020

1 reference

Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis

31 March 2020

1 reference

Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins

31 March 2020

1 reference

Negative and positive regulation of gene expression by mouse histone deacetylase 1

31 March 2020

1 reference

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells

31 March 2020

1 reference

Peptidic small molecule activators of the stress sensor DegS.

31 March 2020

1 reference

Selectivity profiling of DegP substrates and inhibitors

31 March 2020

1 reference

Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.

31 March 2020

1 reference

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

31 March 2020

1 reference

The protease inhibitor Ucf-101 induces cellular responses independently of its known target, HtrA2/Omi

31 March 2020

1 reference

The persisting challenge of selective and specific proteasome inhibition

31 March 2020

1 reference

Inhibition of Wnt signaling by Dishevelled PDZ peptides

31 March 2020

1 reference

Beta strand peptidomimetics as potent PDZ domain ligands

31 March 2020

1 reference

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

31 March 2020

1 reference

Molecular mimics of insulin-like growth factor 1 (IGF-1) for inhibiting IGF-1: IGF-binding protein interactions

31 March 2020

1 reference

Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins

31 March 2020

1 reference

Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins

31 March 2020

1 reference

Allostery and population shift in drug discovery

31 March 2020

1 reference

Searching for new allosteric sites in enzymes

31 March 2020

1 reference

Structural and mechanistic insight into how antibodies inhibit serine proteases.

31 March 2020

1 reference

Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21326199

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21326199

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM3065

1 reference

24 August 2017

1 reference

PubMed ID

21326199