(Q37779571)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

review article

1 reference

title

Structural and mechanistic insight into how antibodies inhibit serine proteases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

3

Daniel Kirchhofer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

2

Charles Eigenbrot

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

language of work or name

English

0 references

publication date

1 September 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

430

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

179-189

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

Targeting proteases: successes, failures and future prospects

9 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Biologic protease inhibitors as novel therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Potent antibody therapeutics by design

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Therapeutic antibodies: successes, limitations and hopes for the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Monoclonal antibodies as innovative therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis".

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Ranibizumab for the treatment of neovascular AMD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Certolizumab pegol: a TNF-{alpha} antagonist for the treatment of moderate-to-severe Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Binding activities of a repertoire of single immunoglobulin variable domains secreted from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Engineered antibody fragments and the rise of single domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

A clogged gutter mechanism for protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Engineering of a macromolecular scaffold to develop specific protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

PEGylated DX-1000: pharmacokinetics and antineoplastic activity of a specific plasmin inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

DX-88 and HAE: a developmental perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Length distribution of CDRH3 in antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

A novel mode of intervention with serine protease activity: targeting zymogen activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Ancylostoma caninum anticoagulant peptide-5: immunolocalization and in vitro neutralization of a major hookworm anti-thrombotic

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Reelin is a serine protease of the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

The B12 anti-tryptase monoclonal antibody disrupts the tetrameric structure of heparin-stabilized beta-tryptase to form monomers that are inactive at neutral pH and active at acidic pH

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Localization of epitopes for monoclonal antibodies to urokinase-type plasminogen activator: relationship between epitope localization and effects of antibodies on molecular interactions of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Isolation and characterization of an inhibitory human monoclonal antibody specific to the urokinase-type plasminogen activator, uPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Inhibition of the hepatitis C virus NS3 protease activity by Fv fragment of antibody 8D4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Unraveling the allosteric mechanism of serine protease inhibition by an antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Structure of an Fab–Protease Complex Reveals a Highly Specific Non-canonical Mechanism of Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Structural insight into distinct mechanisms of protease inhibition by antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Allosteric regulation of proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Crystal structure of the DegS stress sensor: How a PDZ domain recognizes misfolded protein and activates a protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Allosteric activation of DegS, a stress sensor PDZ protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Mechanism of the Ca2+-induced Enhancement of the Intrinsic Factor VIIa Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Thrombin is a Na(+)-activated enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Structural basis of the activation and action of trypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

The structure of thrombin, a chameleon-like proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Heparin modulates the 99-loop of factor IXa: effects on reactivity with isolated Kunitz-type inhibitor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Protein D2 porin of the Pseudomonas aeruginosa outer membrane bears the protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

An antibody specific for coagulation factor IX enhances the activity of the intrinsic factor X-activating complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Discovery of an allosteric site in the caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Small-molecule activators of a proenzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Searching for new allosteric sites in enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Receptor targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Antibiotic proteins of human polymorphonuclear leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Biochemical characterization of AMG 102: a neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Macrophage stimulating protein (MSP) binds to its receptor via the MSP beta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Covalent structure of human haptoglobin: a serine protease homolog

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Hedgehog signaling in development and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Crystal structures of active LytM

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Mapping sonic hedgehog-receptor interactions by steric interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Local protease signaling contributes to neural tube closure in the mouse embryo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Functional roles of human kallikrein-related peptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

Effect of pexelizumab on mortality in patients with acute myocardial infarction or undergoing coronary artery bypass surgery: A systematic overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100634

21 January 2018

Identifiers

DOI

10.1042/BJ20100634

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20704569%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference