(Q36126935)

12 August 2017

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title

The structure of thrombin, a chameleon-like proteinase (English)

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12 August 2017

Bode W

1

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12 August 2017

publication date

9 May 2005

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Journal of Thrombosis and Haemostasis

12 August 2017

published in

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12 August 2017

volume

3

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12 August 2017

issue

11

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12 August 2017

page(s)

2379-2388

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12 August 2017

cites work

The Protein Data Bank

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

A brief historical review of the waterfall/cascade of blood coagulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The waterfall-cascade and autoprothrombin hypotheses of blood coagulation: personal reflections from an observer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

A player of many parts: the spotlight falls on thrombin's structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Coagulation factors and their inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The clot thickens: clues provided by thrombin structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. II. Crystallographic refinement at 1.9 A resolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Protein inhibitors of proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Natural protein proteinase inhibitors and their interaction with proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Crystal structure of bovine trypsinogen at 1-8 A resolution. I. Data collection, application of patterson search techniques and preliminary structural interpretation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Structural basis of the activation and action of trypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-tryp

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Induction of the bovine trypsinogen-trypsin transition by peptides sequentially similar to the N-terminus of trypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Domains specifying thrombin–receptor interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Progress in the development of synthetic thrombin inhibitors as new orally active anticoagulants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Oral direct thrombin inhibitors in clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Proteinase inhibitors from the European medicinal leech Hirudo medicinalis: structural, functional and biomedical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Unexpected binding mode of tick anticoagulant peptide complexed to bovine factor Xa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Crystal structure of the complex between thrombin and the central "E" region of fibrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The interaction of thrombin with fibrinogen. A structural basis for its specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Functional requirements for inhibition of thrombin by antithrombin III in the presence and absence of heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Crystal structure of thrombin bound to heparin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The ternary complex of antithrombin-anhydrothrombin-heparin reveals the basis of inhibitor specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Binding of the bovine basic pancreatic trypsin inhibitor (Kunitz) to human alpha-, beta- and gamma-thrombin; a kinetic and thermodynamic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The discovery of thrombomodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Solution structure of the smallest cofactor-active fragment of thrombomodulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The shape of thrombomodulin and interactions with thrombin as determined by electron microscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Structure of the fifth EGF-like domain of thrombomodulin: An EGF-like domain with a novel disulfide-bonding pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The fourth epidermal growth factor-like domain of thrombomodulin interacts with the basic exosite of protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Amino acid residues in the P6-P'3 region of thrombin-activable fibrinolysis inhibitor (TAFI) do not determine the thrombomodulin dependence of TAFI activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Exosite-driven substrate specificity and function in coagulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Proteases and their inhibitors: traditional research subjects in the Munich area

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Structure of human des(1-45) factor Xa at 2.2 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Crystal structures of uninhibited factor VIIa link its cofactor and substrate-assisted activation to specific interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Crystal structures of the membrane-binding C2 domain of human coagulation factor V

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Catalytic domain structure of vampire bat plasminogen activator: a molecular paradigm for proteolysis without activation cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The ternary microplasmin-staphylokinase-microplasmin complex is a proteinase-cofactor-substrate complex in action

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Crystal structure of the catalytic domain of human plasmin complexed with streptokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The staphylocoagulase family of zymogen activator and adhesion proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Determining the crystal structure of fibrinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1538-7836.2005.01356.X

10.1111/J.1538-7836.2005.01356.X

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference